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首页> 外文期刊>Cureus. >Identifying the Neurogenetic Framework of Crohn's Disease Through Investigative Analysis of the Nucleotide-binding Oligomerization Domain-containing Protein 2 Gene Mutation
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Identifying the Neurogenetic Framework of Crohn's Disease Through Investigative Analysis of the Nucleotide-binding Oligomerization Domain-containing Protein 2 Gene Mutation

机译：通过调查分析核苷酸结合寡聚化结构域的蛋白2基因突变的调查分析来鉴定CROHN疾病的神经源框架

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Among several inflammatory bowel diseases, Crohn’s disease is associated with inflammation?that may take place in any region of the gastrointestinal tract. The inflammatory process is most commonly associated with the ileum, often spreading deep into the bowel tissues, extending into multiple forms, such as strictures and penetrations.?Currently, Crohn’s disease has no known cure. Various medical and surgical procedures?are used to manage the condition. The underlying mechanisms of the disease are yet to be identified, with recent studies suggesting the influence of genetics, environmental factors, and the possible activity of pathogens. Newer studies also offer strong evidence that suggests a relationship between Crohn’s disease and the nucleotide-binding oligomerization domain-containing protein 2 (NOD2) gene, also known as inflammatory bowel disease protein 1 (IBD1) or caspase recruitment domain-containing protein 15 (CARD15). NOD2 is responsible for the mechanism in which the immune system identifies foreign microorganisms through the sensing of pathogen-associated molecular patterns in microorganisms. NOD2 can detect intracellular muramyl dipeptide (MDP) in the bacterial wall, thereby causing an inflammatory response. Three major mutations associated with the NOD2 gene are known to have an influence on Crohn’s disease (SNP8, SNP12, and SNP13). This article will discuss a number of studies to identify whether there is a relationship between Crohn’s disease and the NOD2 gene.
机译：在几种炎性肠病中，Crohn的疾病与炎症有关？可能发生在胃肠道的任何地区。炎症过程最常见于回肠，通常蔓延到肠组织中，延伸到多种形式，如狭窄和渗透。克罗恩病无知的治疗。各种医疗和外科手术？用于管理条件。最近的研究表明遗传，环境因素和病原体可能活性的影响，近期的研究尚未确定该疾病的潜在机制。新的研究还提供了强有力的证据，表明克罗恩病和含核苷酸结合寡聚化结构域的蛋白2（NOD2）基因之间的关系，也称为炎性肠病蛋白1（IBD1）或含胱天冬酶募集域的蛋白15（Card15 ）。 NOD2负责免疫系统通过在微生物中的病原体相关分子模式的感测到外来微生物的机制。 NOD2可以在细菌壁中检测细胞内蛋白偶氮二肽（MDP），从而引起炎症反应。已知与Nod2基因相关的三种主要突变对CroHN病（SNP8，SNP12和SNP13）产生影响。本文将讨论一些研究，以确定克罗恩病和NOD2基因之间是否存在关系。

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