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首页> 外文期刊>Cureus. >Clinical Profiles, Characteristics, and Outcomes of the First 100 Admitted COVID-19 Patients in Pakistan: A Single-Center Retrospective Study in a Tertiary Care Hospital of Karachi
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Clinical Profiles, Characteristics, and Outcomes of the First 100 Admitted COVID-19 Patients in Pakistan: A Single-Center Retrospective Study in a Tertiary Care Hospital of Karachi

机译：第一个100录纳的巴基斯坦患者的临床概况，特征和结果：在卡拉奇的第三节护理医院中的单一中心回顾性研究

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Background and objective COVID-19 is a highly disseminating viral disease imparted by severe acute respiratory syndrome coronavirus 2 (SARS-COV-2), which was declared a global pandemic by the World Health Organization.?In our study, we aimed to describe the clinical characteristics of the first 100 hospitalized patients of confirmed COVID-19 in a developing country. Materials and methods The study included all the admitted patients (n = 100) having COVID-19 polymerase chain reaction (PCR) positive, and evaluated clinical profiles and characteristics of the patients linking to disease severity. Results Out of the 100 patients, 67 were in the ward, 33 were in ICU, 78 of them recovered, while 22 deaths reported. The mean age was 52.58 ± 15.68, with most frequent comorbidities are diabetes and hypertension while frequent symptoms are fever and dry cough. Bilateral lower zone patchy infiltrates are frequent chest radiographic findings. Amongst the patients admitted in ICU, there were significant differences in the total leukocyte count (P = 0.001), neutrophils and lymphocytes (P = 0.001), monocytes (P = 0.027), urea (P = 0.001), creatinine (P = 0.002), neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) increasing with disease severity, lymphocyte-to-monocyte ratio (LMR) and lymphocyte-to-C‐reactive protein ratio (LCR) decreasing with mortalities. Gamma-glutamyl transferase (GGT) followed by aspartate aminotransferase (AST) are frequent hepatic derangements, while C-reactive protein (CRP) levels predicting ICU admission with area under the curve (AUC): 0.806, positive predictive value (PPV): 85.1% and lactate dehydrogenase (LDH) predicting mortality with AUC: 0.877, PPV: 97.3%, while NLR (AUC: 0.806, PPV: 95.8%) for mortality and neutrophils (AUC: 0.773, PPV: 87.5%) for ICU patients. Conclusion A number of factors are linked with disease severity and mortality along with dynamic changes of the laboratory investigations during hospital stay affecting prognosis.
机译：背景和目标Covid-19是由严重急性呼吸综合征冠状病毒2（SARS-COV-2）赋予的高度播种的病毒性疾病，该病毒疾病被世界卫生组织宣布为全球大流行。我们的研究，我们旨在描述在发展中国家的第一个100次住院治疗患者的临床特征。材料和方法该研究包括所有录取的患者（N = 100），具有Covid-19聚合酶链反应（PCR）阳性，并评估与疾病严重程度的患者的临床谱和特征。在100名患者中，67名患者中，在病房中，33名ICU，78人恢复，而22例报告。平均年龄为52.58±15.68，常见的是糖尿病和高血压，而常见的症状是发烧和干咳。双侧下部区域斑块渗透是频繁的胸部放射线摄影结果。在ICU中承认的患者中，全白细胞计数（p = 0.001），中性粒细胞和淋巴细胞（p = <0.001），单核细胞（p = 0.027），尿素（p = <0.001），肌酐（p = 0.002），中性粒细胞到淋巴细胞比（NLR）和血小板到淋巴细胞比（PLR）随疾病严重程度，淋巴细胞对单核细胞比（LMR）和淋巴细胞与C-反应蛋白比（LCR）增加减少死亡率。 γ-谷氨酸转移酶（GGT）随后是天冬氨酸氨基转移酶（AST）是常见的肝紊乱，而C-反应蛋白（CRP）水平预测ICU接受曲线（AUC）的区域（AUC）：0.806，阳性预测值（PPV）：85.1 ％和乳酸脱氢酶（LDH）预测AUC的死亡率：0.877，PPV：97.3％，而ICU患者的死亡率和中性粒细胞（AUC：0.773，PPV：87.5％）的NLR（AUC：0.806，PPV：95.8％）。结论许多因素与疾病严重程度和死亡率相关联，以及医院治疗期间的实验室调查的动态变化。

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