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Modeling the Adhesive Behavior of Platelets During Coagulation ?

机译:在凝血过程中建模血小板的粘合性能

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Platelets play a critical role in the mechanics and dynamics of blood clots, but the exact contribution of individual platelets on the macro-scale mechanics of whole clots is not fully understood. To elucidate the trans-scale relationship, we have developed a discrete element method (DEM)-based model of platelet-platelet and platelet-fibrin interactions that captures the adhesive capacity acquired by platelets upon activation during coagulation. Our simulation results mimic available experimental data and show that platelet-fibrin bonds are nearly thirty times stronger than the strongest platelet-platelet bonds. This cell-scale platelet model sets the framework for a downstream multi-scale model of coagulation.
机译:血小板在血栓的力学和动态中发挥着关键作用,但个体血小板对整个凝块的宏观规模力学的确切贡献尚不完全理解。为了阐明跨尺度关系,我们开发了基于血小板血小板和血小板纤维蛋白相互作用的离散元素(DEM),其捕获血小板在凝血期间激活时填充的粘合剂能力。我们的仿真结果模拟了可用的实验数据,表明血小板纤维蛋白键比最强的血小板粘结率近三十三倍。该细胞级血小板模型设定了下游多尺度凝固模型的框架。

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