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首页> 外文期刊>International journal of infectious diseases : >Systematic review and meta-analysis of diagnostic accuracy of loop-mediated isothermal amplification (LAMP) methods compared with microscopy, polymerase chain reaction and rapid diagnostic tests for malaria diagnosis
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Systematic review and meta-analysis of diagnostic accuracy of loop-mediated isothermal amplification (LAMP) methods compared with microscopy, polymerase chain reaction and rapid diagnostic tests for malaria diagnosis

机译：对环介导等温扩增（灯）方法的系统评价和荟萃分析与显微镜，聚合酶链反应和疟疾诊断的快速诊断测试相比

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Background Diagnosis is a challenging issue for eliminating malaria. Loop-mediated isothermal amplification (LAMP) could be an alternative to conventional methods. This study aimed to evaluate the diagnostic accuracy of LAMP for malaria compared with microscopy, polymerase chain reaction (PCR) and rapid diagnostic tests (RDTs). Methods and design MEDLINE, Web of Science and Scopus were searched from inception to 1 July 2019. Prospective and retrospective, randomised and non-randomised, mono-center and multi-center studies, including symptomatic or asymptomatic patients, that reported one LAMP method and one comparator (microscopy, RDT or PCR) were included. PROSPERO registration number: CRD42017075186. Results Sixty-six studies published between 2006 and 2019 were included, leading to the analysis of 30,641 LAMP tests. The pooled sensitivity of LAMP remained between 96% and 98%, whichever the comparator. The pooled specificity of LAMP was around 95%, but was a little higher if the best PCR studies were considered. The AUC was found to be 0.98, whichever the subgroup of studies was considered. Diagnostic odds ratio (DOR) was found to be around 1000 for all subgroups, except for Plasmodium vivax . Conclusion This meta-analysis confirmed that the LAMP method is robust for diagnosing malaria, both in symptomatic and asymptomatic people. Thus, the impact of LAMP for controlling malaria is expected to be important.
机译：背景技术诊断是消除疟疾的挑战性问题。环介导的等温扩增（灯）可以是常规方法的替代方法。本研究旨在评估疟疾灯的诊断准确性与显微镜，聚合酶链反应（PCR）和快速诊断试验（RDT）相比。方法和设计MEDLINE，科学网站和SCOPUS从初开始到2019年7月1日。预期和回顾性，随机和非随机化，单中心和多中心研究，包括症状或无症状患者，报告了一盏灯法和包括一个比较器（显微镜，RDT或PCR）。 Prospero注册号：CRD42017075186。结果2006年至2019年期间发布的66项研究，导致30,641盏灯测试的分析。灯的汇集敏感性仍保持在96％至98％之间，无论比较器。灯的汇集特异性约为95％，但如果考虑了最佳的PCR研究，则略高。发现AUC是> 0.98，无论考虑研究的子组。除疟原虫vivax外，发现诊断差距比（DOR）为所有亚组约为1000。结论该元分析证实，灯泡方法对症状和无症状人员诊断疟疾是强大的。因此，预计灯对控制疟疾的影响将是重要的。

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