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首页> 外文期刊>International Journal of Molecular Sciences >Antimicrobial Peptides as New Combination Agents in Cancer Therapeutics: A Promising Protocol against HT-29 Tumoral Spheroids
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Antimicrobial Peptides as New Combination Agents in Cancer Therapeutics: A Promising Protocol against HT-29 Tumoral Spheroids

机译：抗菌肽作为癌症治疗剂中的新组合剂：对抗HT-29肿瘤球体的有前途的方案

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摘要

Antimicrobial peptides are molecules synthetized by a large variety of organisms as an innate defense against pathogens. These natural compounds have been identified as promising alternatives to widely used molecules to treat infections and cancer cells. Antimicrobial peptides could be viewed as future chemotherapeutic alternatives, having the advantage of low propensity to drug resistance. In this study, we evaluated the efficiency of the antimicrobial peptide gramicidin A (GA) and the anticancer drug, doxorubicin (Doxo) against the spheroids from colorectal cancer cells (HT-29). The two drugs were applied separately against HT-29 spheroids as well as together to determine if they can act synergistically. The spheroid evolution, cell viability, and ATP levels were monitored at 24 and 48 h after the applied treatments. The results show significant drops in cell viability and cellular ATP levels for all the experimental treatments. The simultaneous use of the two compounds (GA and Doxo) seems to cause a synergistic effect against the spheroids.
机译：抗微生物肽是由各种各样的生物合成的分子作为对抗病原体的先天性防御。这些天然化合物已被鉴定为广泛使用的分子以治疗感染和癌细胞的有前途的替代方案。抗微生物肽可以被视为未来的化学治疗替代方法，其具有低抗药性倾向的优点。在这项研究中，我们评估了抗微生物肽禾本霉素A（GA）和抗癌药物，多柔比星（DOXO）与结肠直肠癌细胞（HT-29）的球状体的效率。这两种药物分别用于HT-29球体，以及一起确定它们是否可以协同作用。在施加处理后24和48小时监测球形进化，细胞活力和ATP水平。结果显示了所有实验治疗的细胞活力和细胞ATP水平的显着下降。同时使用两种化合物（GA和DOXO）似乎对球状体引起协同效应。

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