How Kinesin-1 Utilize the Energy of Nucleotide: The Conformational Changes and Mechanochemical Coupling in the Unidirectional Motion of Kinesin-1

Jingyu Qin; Hui Zhang; Yizhao Geng; Qing Ji

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How Kinesin-1 Utilize the Energy of Nucleotide: The Conformational Changes and Mechanochemical Coupling in the Unidirectional Motion of Kinesin-1

机译：Kinesin-1如何利用核苷酸的能量：在Kinesin-1的单向运动中的构象变化和机械化学耦合

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Kinesin-1 is a typical motile molecular motor and the founding member of the kinesin family. The most significant feature in the unidirectional motion of kinesin-1 is its processivity. To realize the fast and processive movement on the microtubule lattice, kinesin-1 efficiently transforms the chemical energy of nucleotide binding and hydrolysis to the energy of mechanical movement. The chemical and mechanical cycle of kinesin-1 are coupled to avoid futile nucleotide hydrolysis. In this paper, the research on the mechanical pathway of energy transition and the regulating mechanism of the mechanochemical cycle of kinesin-1 is reviewed.

机译：Kinesin-1是典型的运动分子电机和Kinesin家族的创始成员。 Kinesin-1单向运动中最重要的特征是其处理能力。为了实现微管晶格上的快速和加工运动，Kinesin-1有效地将核苷酸结合和水解的化学能与机械运动的能量转化为能量。 Kinesin-1的化学和机械循环耦合，以避免徒劳核苷酸水解。本文综述了能源转变力学途径的研究及Kinesin-1的机械化学循环调节机理。

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《International Journal of Molecular Sciences》 |2020年第18期|共18页
作者
Jingyu Qin; Hui Zhang; Yizhao Geng; Qing Ji;
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Kinesin-1nucleotidemicrotubulemechanochemical couplingneck linkerconformational change;

机译：Kinesin-1nucerotidImpicrotubulememensochemical incomingNedNeck LinkerConformational变化;

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专利

1. The Kinesin-1 tail conformationally restricts the nucleotide pocket. [J] . Wong YL, Dietrich KA, Naber N, Biophysical Journal . 2009,第7期

机译：Kinesin-1尾部构象限制了核苷酸的口袋。
2. Kinesin-1 structural organization and conformational changes revealed by FRET stoichiometry in live cells [J] . Dawen Cai, Adam D. Hoppe, Joel A. Swanson, Journal of cell biology . 2007,第1期

机译：FRET化学计量学在活细胞中显示Kinesin-1的结构组织和构象变化
3. Kinesin-1–syntaphilin coupling mediates activity-dependent regulation of axonal mitochondrial transport [J] . Yanmin Chen, Zu-Hang Sheng Journal of cell biology . 2013,第2期

机译：Kinesin-1–Syntaphilin偶联介导轴突线粒体运输的活性依赖调节。
4. Conformation, motion and base-to-base excitation energy transfer in DNA [C] . Thomas M. Nordlund, Daguang Xu, Kervin O. Evans Fluorescence Science and Technology . 2000

机译：DNA中的构象，运动和基础激发能量转移
5. The Coupling of Conformational Exchange Motions and Phosphoryl Transfer in Protein Tyrosine Phosphatases. [D] . Whittier, Sean Kenneth. 2014

机译：蛋白质酪氨酸磷酸酶中的构象交换运动和磷酰基转移的耦合。
6. How Kinesin-1 Utilize the Energy of Nucleotide: The Conformational Changes and Mechanochemical Coupling in the Unidirectional Motion of Kinesin-1 [O] . Jingyu Qin, Hui Zhang, Yizhao Geng, 2020

机译：Kinesin-1如何利用核苷酸的能量：在Kinesin-1的单向运动中的构象变化和机械化学耦合
7. How Kinesin-1 Utilize the Energy of Nucleotide: The Conformational Changes and Mechanochemical Coupling in the Unidirectional Motion of Kinesin-1 [O] . Jingyu Qin, Hui Zhang, Yizhao Geng, 2020

机译：Kinesin-1如何利用核苷酸的能量：在Kinesin-1的单向运动中的构象变化和机械化学耦合
8. Potential Energy Surfaces of Substituted Anilines: Conformational Energies, Deuteration Effects, Internal Rotation, and Torsional Motion. (Reannouncement with New Availability Information). [R] . Disselkamp, R., Im, H. S., Bernstein, E. R. 1992

机译：取代苯胺的势能面：构象能，氘化效应，内部旋转和扭转运动。（重新公布新的可用性信息）。

How Kinesin-1 Utilize the Energy of Nucleotide: The Conformational Changes and Mechanochemical Coupling in the Unidirectional Motion of Kinesin-1

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