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首页> 外文期刊>International Journal of Molecular Sciences >Antibiotic Treatment Prior to Injury Improves Post-Traumatic Osteoarthritis Outcomes in Mice
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Antibiotic Treatment Prior to Injury Improves Post-Traumatic Osteoarthritis Outcomes in Mice

机译：损伤前的抗生素治疗改善了小鼠的创伤后骨关节炎结果

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Osteoarthritis (OA) is a painful and debilitating disease characterized by the chronic and progressive degradation of articular cartilage. Post-traumatic OA (PTOA) is a secondary form of OA that develops in ~50% of cases of severe articular injury. Inflammation and re-occurring injury have been implicated as contributing to the progression of PTOA after the initial injury. However, there is very little known about external factors prior to injury that could affect the risk of PTOA development. To examine how the gut microbiome affects PTOA development we used a chronic antibiotic treatment regimen starting at weaning for six weeks prior to ACL rupture, in mice. A six-weeks post-injury histological examination showed more robust cartilage staining on the antibiotic (AB)-treated mice than the untreated controls (VEH), suggesting slower disease progression in AB cohorts. Injured joints also showed an increase in the presence of anti-inflammatory M2 macrophages in the AB group. Molecularly, the phenotype correlated with a significantly lower expression of inflammatory genes Tlr5, Ccl8, Cxcl13, and Foxo6 in the injured joints of AB-treated animals. Our results indicate that a reduced state of inflammation at the time of injury and a lower expression of Wnt signaling modulatory protein, Rspo1, caused by AB treatment can slow down or improve PTOA outcomes.
机译：骨关节炎（OA）是一种痛苦和衰弱的疾病，其特征在于关节软骨的慢性和渐进性降解。后创伤后OA（PTOA）是OA的次要形式，可在〜50％的严重关节损伤病例中发展。炎症和重新发生的损伤已涉及初始损伤后促进PTOA的进展。然而，在损伤之前对外部因素有所了解，这可能会影响PTOA发展的风险。为了检查肠道微生物组的影响如何影响PTOA开发，我们使用慢性抗生素治疗方案在acl破裂之前在术前六周开始，小鼠。六周后损伤后组织学检查显示出比未处理的对照（VAV）的抗生素（AB）-Treated小鼠更强大的软骨染色，表明AB队列中的疾病进展较慢。受伤的关节还显示出AB组抗炎M2巨噬细胞存在的增加。分子型与炎症基因TLR5，CCL8，CXCL13和FoxO6的显着降低的表达相关，在受伤的动物的受损关节中。我们的结果表明，由AB治疗引起的损伤时损伤时炎症状态和Wnt信号调节蛋白的较低表达可以减缓或改善PTOA结果。

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