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首页> 外文期刊>International Journal of Molecular Sciences >Non-Coding RNAs, a Novel Paradigm for the Management of Gastrointestinal Stromal Tumors
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Non-Coding RNAs, a Novel Paradigm for the Management of Gastrointestinal Stromal Tumors

机译：非编码RNA，一种用于管理胃肠道基质肿瘤的新型范式

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摘要

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal malignancies found in the gastrointestinal tract. At a molecular level, most GISTs are characterized by gain-of-function mutations in V-Kit Hardy–Zuckerman 4 Feline Sarcoma Viral Oncogene Homolog ( KIT ) and Platelet Derived Growth Factor Receptor Alpha ( PDGFRA ), leading to constitutive activated signaling through these receptor tyrosine kinases, which drive GIST pathogenesis. In addition to surgery, treatment with the tyrosine kinase inhibitor imatinib forms the mainstay of GIST treatment, particularly in the advanced setting. Nevertheless, the majority of GISTs develop imatinib resistance. Biomarkers that indicate metastasis, drug resistance and disease progression early on could be of great clinical value. Likewise, novel treatment strategies that overcome resistance mechanisms are equally needed. Non-coding RNAs, particularly microRNAs, can be employed as diagnostic, prognostic or predictive biomarkers and have therapeutic potential. Here we review which non-coding RNAs are deregulated in GISTs, whether they can be linked to specific clinicopathological features and discuss how they can be used to improve the clinical management of GISTs.
机译：胃肠道间质瘤（GIST）是胃肠道中最常见的间充质恶性肿瘤。在分子水平下，大多数GIST的特征在于V-kit Hardy-Zuckerman 4猫科动物病毒癌基因同源物（试剂盒）和血小板衍生的生长因子受体α（PDGFRA）中的功能突变，导致通过这些形成的本构激活信号传导受体酪氨酸激酶，驱动剂的致病机制。除了手术外，用酪氨酸激酶抑制剂伊马替尼的治疗形成了GIST治疗的主干，特别是在先进的环境中。尽管如此，大多数GISTS都会发展伊马替尼阻力。早期表明转移，耐药性和疾病进展的生物标志物可能具有巨大的临床价值。同样，克服抗性机制的新型治疗策略同样需要。非编码RNA，特别是MicroRNA，可用作诊断，预后或预测生物标志物并且具有治疗潜力。在这里，我们审查了哪些未编码的RNA在g患者中解除注释，无论它们是否可以与特定的临床病理特征相关联，并讨论它们如何用于改善名人的临床管理。

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