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首页> 外文期刊>International Journal of Molecular Sciences >Covid-19: The Rollercoaster of Fibrin(Ogen), D-Dimer, Von Willebrand Factor, P-Selectin and Their Interactions with Endothelial Cells, Platelets and Erythrocytes
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Covid-19: The Rollercoaster of Fibrin(Ogen), D-Dimer, Von Willebrand Factor, P-Selectin and Their Interactions with Endothelial Cells, Platelets and Erythrocytes

机译：Covid-19：纤维蛋白（ELIGON），D-DIMOR，VON WILLEBRAND系数，P-SELETIN及其与内皮细胞，血小板和红细胞相互作用的过山运动

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Severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2), also known as coronavirus disease 2019 (COVID-19)-induced infection, is strongly associated with various coagulopathies that may result in either bleeding and thrombocytopenia or hypercoagulation and thrombosis. Thrombotic and bleeding or thrombotic pathologies are significant accompaniments to acute respiratory syndrome and lung complications in COVID-19. Thrombotic events and bleeding often occur in subjects with weak constitutions, multiple risk factors and comorbidities. Of particular interest are the various circulating inflammatory coagulation biomarkers involved directly in clotting, with specific focus on fibrin(ogen), D-dimer, P-selectin and von Willebrand Factor (VWF). Central to the activity of these biomarkers are their receptors and signalling pathways on endothelial cells, platelets and erythrocytes. In this review, we discuss vascular implications of COVID-19 and relate this to circulating biomarker, endothelial, erythrocyte and platelet dysfunction. During the progression of the disease, these markers may either be within healthy levels, upregulated or eventually depleted. Most significant is that patients need to be treated early in the disease progression, when high levels of VWF, P-selectin and fibrinogen are present, with normal or slightly increased levels of D-dimer (however, D-dimer levels will rapidly increase as the disease progresses). Progression to VWF and fibrinogen depletion with high D-dimer levels and even higher P-selectin levels, followed by the cytokine storm, will be indicative of a poor prognosis. We conclude by looking at point-of-care devices and methodologies in COVID-19 management and suggest that a personalized medicine approach should be considered in the treatment of patients.
机译：严重急性呼吸综合征冠状病毒2（SARS-COV-2），也称为冠状病毒疾病2019（Covid-19）诱导的感染，与各种凝血病强烈有关，可能导致出血和血小板减少或高凝和血栓形成。血栓形成和出血或血栓形成病理是Covid-19中急性呼吸综合征和肺并发症的显着伴奏。血栓形成事件和出血通常发生在具有薄弱的构成，多种风险因素和合并症的受试者中。特别令人兴趣的是各种循环炎症凝血生物标志物直接涉及凝血，特别关注纤维蛋白（ELOGEN），D-二聚体，P-SELECTIN和von WILLEBRAND系数（VWF）。这些生物标志物的活动的核心是其受体和内皮细胞，血小板和红细胞的信号通路。在本文中，我们讨论了Covid-19的血管意义，并将其与循环生物标志物，内皮，红细胞和血小板功能障碍相关联。在疾病的进展过程中，这些标志物可以是健康水平，上调或最终耗尽。最重要的是，患者需要在疾病进展中早期治疗，当存在高水平的VWF，P-选择素和纤维蛋白原，D-二聚体的正常或略微增加（但是，D-二聚体水平将迅速增加。疾病的进展）。具有高D-二聚体水平的VWF和纤维蛋白原耗尽，甚至更高的P-SELETIN水平，其次是细胞因子风暴的进展将表明预后差。我们通过查看Covid-19管理中的护理点装置和方法，并建议应考虑治疗患​​者的个性化药物方法。

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