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首页> 外文期刊>Nature Communications >Bacterial AB5 toxins inhibit the growth of gut bacteria by targeting ganglioside-like glycoconjugates
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Bacterial AB5 toxins inhibit the growth of gut bacteria by targeting ganglioside-like glycoconjugates

机译：细菌AB5毒素通过靶向神经节苷脂样糖缀合物来抑制肠细菌的生长

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The AB5 toxins cholera toxin (CT) from Vibrio cholerae and heat-labile enterotoxin (LT)from enterotoxigenic Escherichia coli are notorious for their roles in diarrheal disease, buttheir effect on other intestinal bacteria remains unexplored. Another foodborne pathogen,Campylobacter jejuni, can mimic the GM1 ganglioside receptor of CT and LT. Here wedemonstrate that the toxin B-subunits (CTB and LTB) inhibit C. jejuni growth by bindingto GM1-mimicking lipooligosaccharides and increasing permeability of the cell membrane.Furthermore, incubation of CTB or LTB with a C. jejuni isolate capable of altering its lipooligosaccharidestructure selects for variants lacking the GM1 mimic. Examining the chickenGI tract with immunofluorescence microscopy demonstrates that GM1 reactive structuresare abundant on epithelial cells and commensal bacteria, further emphasizing the relevanceof this mimicry. Exposure of chickens to CTB or LTB causes shifts in the gut microbialcomposition, providing evidence for new toxin functions in bacterial gut competition.
机译：来自肠胆碱的AB5毒素霍乱毒素（CT）来自Enterotoxigenic大肠杆菌的肠胆碱和热不稳定肠毒素（LT）对于腹泻病中的作用是臭名昭着的，但对其他肠道细菌的影响仍未探索。另一种食源性病原体，Campylobacter Jejuni可以模仿CT和LT的GM1神经节苷脂受体。以下威胁表明，毒素B亚基（CTB和LTB）通过结合GM1模仿脂质多糖和增加细胞膜的渗透性，培养的CTB或LTB与C. Jejuni分离物的孵育能够改变其脂肪乳液的渗透率选择缺少GM1模拟的变体。检查具有免疫荧光显微镜的鸡氏菌证明了GM1对上皮细胞和非团结细菌丰富的反应性结构，进一步强调了这种模仿的相关性。鸡暴露于CTB或LTB导致肠道微生物组织中的变化，为细菌肠道竞争中的新毒素功能提供了证据。

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