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首页> 外文期刊>Molecules >Ferula L. Plant Extracts and Dose-Dependent Activity of Natural Sesquiterpene Ferutinin: From Antioxidant Potential to Cytotoxic Effects
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Ferula L. Plant Extracts and Dose-Dependent Activity of Natural Sesquiterpene Ferutinin: From Antioxidant Potential to Cytotoxic Effects

机译：Forula L.植物提取物和天然筛分培养蛋白酶的剂量依赖性活性：从抗氧化潜力到细胞毒性作用

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The employment studies of natural extracts in the prevention and treatment of several diseases highlighted the role of different species of genus Ferula L., belonging to the Apiaceae family, dicotyledonous plants present in many temperate zones of our planet. Ferula communis L. is the main source of sesquiterpene ferutinin, a bioactive compound studied both in vitro and in vivo, because of different effects, such as phytoestrogenic, antioxidant, anti-inflammatory, but also antiproliferative and cytotoxic activity, performed in a dose-dependent and cell-dependent way. The present review will focus on the molecular mechanisms involved in the different activities of Ferutinin, starting from its antioxidant potential at low doses until its ionophoric property and the subsequent mitochondrial dysfunction induced through administration of high doses, which represent the key point of its anticancer action. Furthermore, we will summarize the data acquired from some experimental studies on different cell types and on several diseases. The results obtained showed an important antioxidant and phytoestrogenic regulation with lack of typical side effects related to estrogenic therapy. The preferential cell death induction for tumor cell lines suggests that ferutinin may have anti-neoplastic properties, and may be used as an antiproliferative and cytotoxic agent in an estrogen dependent and independent manner. Nevertheless, more data are needed to clearly understand the effect of ferutinin in animals before using it as a phytoestrogen or anticancer drug.
机译：预防和治疗几种疾病中的自然提取物的就业研究突出了不同种类的Ferula L.的作用，属于苹果酱家族，在我们星球的许多温带区域中存在的二象属植物。 Ferula Communis L.是倍二萜Ferutinin的主要来源，一种生物活性化合物在体外和体内研究，因为不同的疗法，例如植物雌激素，抗氧化剂，抗炎，也是抗增殖和细胞毒性活性，在剂量中进行 - 依赖和细胞依赖的方式。本综述将专注于氟丁蛋白不同活动中涉及的分子机制，从其低剂量的抗氧化潜力开始，直到其对离子性质和通过施用高剂量诱导的随后的线粒体功能障碍，这代表其抗癌动作的关键点。此外，我们将总结从一些关于不同细胞类型和几种疾病的一些实验研究中获得的数据。所得到的结果显示出具有与雌激素治疗相关的典型副作用缺乏典型的抗氧化和植物发酵调节。肿瘤细胞系的优先细胞死亡诱导表明，Ferutinin可具有抗肿瘤性质，并且可以用作雌激素依赖性和独立方式的抗增殖和细胞毒性剂。然而，需要更多的数据来清楚地了解在使用它作为一种植物雌激素或抗癌药物之前动物的苯丁蛋白在动物的作用。

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