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首页> 外文期刊>RSC Advances >A series of Mn(i) photo-activated carbon monoxide-releasing molecules with benzimidazole coligands: synthesis, structural characterization, CO releasing properties and biological activity evaluation
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A series of Mn(i) photo-activated carbon monoxide-releasing molecules with benzimidazole coligands: synthesis, structural characterization, CO releasing properties and biological activity evaluation

机译：一系列Mn（i）苯并咪唑Coligands的光活性炭一氧化物 - 一氧化碳分子：合成，结构表征，CO释放性能和生物活性评价

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摘要

Five Mn( I ) photo-activated carbon monoxide-releasing molecules (photo-CORMs) with benzimidazole coligands, namely [MnBr(CO) _(3) L1] ( 1 , L1 = 2-(2-pyridyl)benzimidazole), [Mn(CO) _(2) L1(PPh _(3) ) _(2) ](ClO _(4) ) ( 2 ), [MnBr(CO) _(3) L2] ( 3 , L2 = 2,2′-bisbenzimidazole), [MnBr(CO) _(3) L3]·CH _(3) OH ( 4 , L3 = 2,6-bis(benzimidazole-2′-yl)pyridine) and fac -[MnBr(CO) _(3) L4] ( 5 , L4 = 2,4-bis(benzimidazole-2′-yl) pyridine) were synthesized by reactions of MnBr(CO) _(5) with complexes L1–L4, respectively, and characterized via single crystal X-ray diffraction, elemental analysis, ~(1) H-NMR, ~(13) C-NMR, IR, UV-vis and fluorescence spectroscopy. The CO-release properties of 1–5 were investigated using the myoglobin assay and CO detection, and the results show that all of the complexes could release CO rapidly upon exposure to 365 nm UV light. Comparing their half-lives of CO release, we found that increasing the degree of unsaturation and conjugation of the ligand frame could be advantageous for prolonging the time of CO-release, and that the luminescence intensity of 1–5 could gradually be enhanced. The cellular fluorescence imaging tests demonstrate that these Mn( I ) photo-CORMs can be taken up by human liver cells (HL-7702) and liver cancer cells (SK-Hep1), and exhibit good capabilities for bioimaging. A cell viability assay for SK-Hep1 shows that the anticancer activity of 3 is better than that of other complexes.
机译：用苯并咪唑Coligands（即[MnBr（Co）_（3）L1]（1，L1 = 2-（2-吡啶基）苯并咪唑），[MnBr（CO）_（3）L1]（1，L1 = 2-（2-吡啶基）苯并咪唑），[ Mn（CO）_（2）L1（PPH _（3））_（2））（CLO _（4））（2），[MNBR（CO）_（3）L2]（3，L2 = 2， 2'-Bisbenendimidazole），[MNBR（CO）_（3）L3]·CH _（3）OH（4，L3 = 2,6-双（苯并咪唑-2'-Y1）吡啶）和FAC - [MNBR（ CO）_（3）L4]（5，L4 =​​ 2,4-双（苯并咪唑-2'-Y1）吡啶分别与复合物L1-L4的MNBR（CO）_（5）的反应合成，并且通过单晶X射线衍射，元素分析，〜（1）H-NMR，〜（13）C-NMR，IR，UV-Vis和荧光光谱。使用肌球蛋白测定和CO检测研究了1-5的共释性特性，结果表明，所有复合物都可以在暴露于365nm紫外光时快速释放CO。比较他们的联合释放的半衰期，我们发现增加配体框架的不饱和度和缀合可能是有利的，延长共同释放的时间，并且可以逐渐增强1-5的发光强度。细胞荧光成像试验表明，这些Mn（I）光纤维可由人肝细胞（HL-7702）和肝癌细胞（SK-HEP1）占用，并表现出良好的生物成像能力。 SK-HEP1的细胞活力测定表明，3的抗癌活性优于其他复合物的抗癌活性。

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