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首页> 外文期刊>RSC Advances >The solid-state proton NMR study of bone using a dipolar filter: apatite hydroxyl content versus animal age
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The solid-state proton NMR study of bone using a dipolar filter: apatite hydroxyl content versus animal age

机译：使用偶极过滤器的骨固态质子NMR研究：磷灰石羟基含量与动物时代

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摘要

The hydroxyl content of bone apatite mineral has been measured using proton solid-state NMR performed with a multiple-pulse dipolar filter under slow magic angle spinning (MAS). This new method succeeded in resolving and relatively enhancing the main hydroxyl peak at ca. 0 ppm from whole bone, making it amenable to rigorous quantitative analysis. The proposed methodology, involving line fitting, the measurement of the apatite concentration in the studied material and adequate calibration, was proved to be convenient and suitable for monitoring bone mineral hydroxylation in different species and over the lifetime of the animal. It was found that the hydroxyl content in the cranial bone mineral of pig and rats remained in the 5–10% range, with reference to stoichiometric hydroxyapatite. In rats, the hydroxyl content showed a non-monotonic increase with age, which was governed by biological processes rather than by chemical, thermodynamically driven apatite maturation.
机译：通过在慢魔角旋转（MAS）下用多脉冲双极过滤器进行质子固态NMR测量骨磷灰石矿物的羟基含量。这种新方法成功地解析了CA的主要羟基峰。来自全骨0 ppm，使其适用于严格的定量分析。所提出的方法，涉及研究的方法，测量研究的材料中的磷灰石浓度和足够的校准，是方便，适用于在不同物种和动物的寿命中监测骨矿物羟化。发现猪和大鼠颅骨矿物中的羟基含量在5-10％范围内，参照化学计量羟基磷灰石。在大鼠中，羟基含量随着年龄的年龄显示出非单调的增加，其受生物过程而不是化学品，热力学驱动的磷灰石成熟。

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