Aza-BODIPY probe for selective visualization of cyclooxygenase-2 in cancer cells

Thitima Pewklang; Kantapat Chansaenpak; Rung-Yi Lai; Parinya Noisa; Anyanee Kamkaew

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Aza-BODIPY probe for selective visualization of cyclooxygenase-2 in cancer cells

机译：AZA-BODIPY探针，用于在癌细胞中选择性可视化环氧氧酶-2

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AZB-IMC _(2) was developed as a COX-2 specific probe that exhibited a brighter fluorescence signal in cancer cells that overexpress COX-2 compared to normal cells. Oxidative stress agent-treated inflamed cell lines inducing high COX-2 levels revealed an enhanced fluorescence signal. Inhibitory studies showed a markedly reduced fluorescence intensity in cancer cells. The results suggested that AZB-IMC _(2) could be developed as a promising molecular tool for imaging guiding during surgery.

机译：AZB-IMC _（2）被开发为COX-2特异性探针，其在与正常细胞相比过表达COX-2的癌细胞中的较亮荧光信号。诱导高COX-2水平的氧化应激剂处理的发炎细胞系揭示了增强的荧光信号。抑制性研究表明癌细胞中明显降低的荧光强度。结果表明AZB-IMC _（2）可以作为在手术期间进行成像的有希望的分子工具。

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《RSC Advances》 |2019年第24期|共6页
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Thitima Pewklang; Kantapat Chansaenpak; Rung-Yi Lai; Parinya Noisa; Anyanee Kamkaew;
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1. Aza-BODIPY probe for selective visualization of cyclooxygenase-2 in cancer cells [J] . Pewklang Thitima, Chansaenpak Kantapat, Lai Rung-Yi, RSC Advances . 2019,第24期

机译：AZA-BODIPY探针，用于在癌细胞中选择性可视化环氧氧酶-2
2. Near-infrared aza-BODIPY fluorescent probe for selective Cu2+ detection and its potential in living cell imaging [J] . Tachapermpon Yordkhuan, Thavornpradit Sopida, Charoenpanich Adisri, Dalton transactions: An international journal of inorganic chemistry . 2017,第46期

机译：用于选择性Cu2 +检测的近红外AZA-BOBIPY荧光探针及其活性细胞成像的潜力
3. Fluorescent probes towards selective cathepsin B detection and visualization in cancer cells and patient samples [J] . Marcin Poreba, Katarzyna Groborz, Matej Vizovisek, Chemical science . 2019,第36期

机译：荧光探针对癌细胞和患者样品中的选择性组织蛋白酶B检测和可视化
4. DMNQ S-64 Induces Apoptosis via Caspase Activation and Cyclooxygenase-2 Inhibition in Human Nonsmall Lung Cancer Cells [C] . EU-SOO LIM, YUN-HEE RHEE, MIN-KYU PARK, . 2007

机译：DMNQ S-64通过胱天蛋白酶激活和环氧合酶2抑制诱导人类非小肺癌细胞凋亡。
5. The role of p38 mitogen activated protein kinase in post-transcriptional regulation of cyclooxygenase-2 in intleukin-1beta and tumor necrosis factor-alpha stimulated prostate cancer cell lines. [D] . Khatri, Jitender. 2011

机译：p38丝裂原活化蛋白激酶在intleukin-1beta和肿瘤坏死因子-α刺激的前列腺癌细胞系中环氧合酶2的转录后调控中的作用。
6. Fluorescent probes towards selective cathepsin B detection and visualization in cancer cells and patient samples [O] . Marcin Poreba, Katarzyna Groborz, Matej Vizovisek, 2019

机译：用于癌细胞和患者样品中选择性组织蛋白酶B检测和可视化的荧光探针
7. Aza-BODIPY probe for selective visualization of cyclooxygenase-2 in cancer cells [O] . Thitima Pewklang, Kantapat Chansaenpak, Rung-Yi Lai, 2019

机译：AZA-BODIPY探针，用于在癌细胞中选择性可视化环氧氧酶-2

Aza-BODIPY probe for selective visualization of cyclooxygenase-2 in cancer cells

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