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The use of fractionated Kraft lignin to improve the mechanical and biological properties of PVA-based scaffolds

机译:使用分馏的牛皮纸来改善PVA基支架的机械和生物学性质

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The mechanical properties of poly(vinyl alcohol) (PVA)-based scaffolds were successfully improved. The improvements in mechanical properties correlated with the amount of Kraft lignin in PVA matrices. The critical property for any scaffold is its capacity to allow cells to ingrow and survive within its internal structure. The ingrowth of cells was tested using bioreactors creating simulated in vivo conditions. In the context of all the mentioned parameters, the most advantageous properties were exhibited by the scaffold containing 99 wt% PVA and 1 wt% Kraft lignin. The composites with 1 wt% Kraft lignin exhibited sufficient mechanical stability, a lack of cytotoxicity, and mainly the ability to allow the ingrowth of cells into the scaffold in a rotation bioreactor.
机译:成功改善了聚(乙烯醇)(PVA)的支架的机械性能。机械性能的改善与PVA基质中的牛皮油量相关。任何支架的关键性质都是其允许细胞在其内部结构内产生并存活的能力。使用在体内条件下模拟的生物反应器测试细胞的向环境。在所有提到的参数的上下文中,通过含有99wt%PVA和1wt%牛皮蛋白的支架显示出最有利的性质。具有1wt%牛皮纸的复合材料表现出足够的机械稳定性,缺乏细胞毒性,主要是允许在旋转生物反应器中允许细胞到支架中的能力。

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