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首页> 外文期刊>RSC Advances >In vivo targeting of breast cancer with a vasculature-specific GQDs/hMSN nanoplatform
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In vivo targeting of breast cancer with a vasculature-specific GQDs/hMSN nanoplatform

机译：体内靶向血管系统特异性GQDS / HMSN纳米纳米癌的靶向乳腺癌

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According to our previous experiment, graphene quantum dots capped in hollow mesoporous silica nanoparticles, denoted as GQDs@hMSN, and its conjugates exhibited great potential for medical applications due to their commendable biocompatibility. Due to the fluorescence and structural stability, and enormous porosity, polyethylene glycol (PEG) modified GQDs@hMSN (GQDs@hMSN-PEG) is a good candidate in a drug carrying and delivery system. However, the goal of targeted drug delivery couldn't be achieved simply by utilizing the enhanced permeability and retention (EPR) effect of tumors. In this study, GQDs@hMSN-PEG was further functionalized with vascular endothelial growth factor antibodies (VEGF Abs) for VEGF targeting of breast tumors. Doxorubicin (DOX) was loaded into GQDs@hMSN-VEGF Abs with a drug loading capacity of 0.80 mg DOX per mg GQDs@hMSN. With GQDs as the fluorescent source, GQDs@hMSN-VEGF Abs demonstrated strong fluorescence intensity in VEGF-positive cells. Results from in vitro and in vivo targeting experiments indicated that GQDs@hMSN-VEGF Abs had high specificity on tumor vasculature, and it could be used as an image-guidable, tumor-selective delivery nanoplatform for breast cancer.
机译：根据我们以前的实验，在中空介孔二氧化硅纳米粒子中盖上的石墨烯量子点，表示为GQDS @ HMSN，其缀合物由于其值得称道的生物相容性而表现出巨大的医疗应用潜力。由于荧光和结构稳定性，并且巨大的孔隙率，聚乙二醇（PEG）改性GQDS @ HMSN（GQDS @ HMSN-PEG）是药物承载和输送系统中的良好候选者。然而，通过利用肿瘤的增强渗透率和保留（EPR）效应，不能仅实现靶向药物递送的目的。在该研究中，GQDS @ HMSN-PEG与血管内皮生长因子抗体（VEGF ABS）进一步官能化，用于VEGF靶向乳腺肿瘤。多柔比星（DOX）加载到GQDS @ HMSN-VEGF ABS中，药物负载容量为每Mg GQDS @ HMSN 0.80mg DOX。通过GQD作为荧光源，GQDS @ HMSN-VEGF ABS在VEGF阳性细胞中显示出强烈的荧光强度。来自体外和体内靶向实验的结果表明，GQDS @ HMSN-VEGF ABS对肿瘤脉管系统具有很高的特异性，可用作乳腺癌的图像引导，肿瘤选择性递送纳米片。

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