• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>RSC Advances >Surface hemocompatible modification of polysulfone membrane via covalently grafting acrylic acid and sulfonated hydroxypropyl chitosan
【24h】

Surface hemocompatible modification of polysulfone membrane via covalently grafting acrylic acid and sulfonated hydroxypropyl chitosan

机译：通过共价接枝丙烯酸和磺化羟丙基壳聚糖的聚砜膜的表面血液相成改性

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In this study, acrylic acid (AA) and sulfonated hydroxypropyl chitosan (SHPCS) were covalently grafted on the PSf membrane surface to improve its hemocompatibility. First, the modified AA-PSf membrane was obtained through the Friedel–Craft reaction between acrylic acid and the PSf membrane surface. Then, the modified SHPCS-AA-PSf membrane was prepared by grafting SHPCS onto the AA-PSf membrane surface via the dehydration acylation of the carboxyl group of the AA-PSf membrane with the amino group of SHPCS. ATR-FTIR and XPS measurements confirmed that the –COOH group and SHPCS were successfully grafted onto the surface of the PSf membrane. The modified PSf membranes showed suppressed platelet adhesion and lower protein adsorption (161 μg cm ~(?2) ) compared with the pristine PSf membrane (341 μg cm ~(?2) ). Hemocompatibility testing showed that modified membrane materials had a prolonged clotting time, plasma recalcification time (PRT), activated partial thromboplastin time (APTT), thrombin time (TT), and prothrombin time (PT). All of these results indicated that the surface modification of the PSf membrane with acrylic acid and SHPCS had good hemocompatibility and anticoagulant property.
机译：在该研究中，丙烯酸（AA）和磺化羟丙基壳聚糖（SHPC）在PSF膜表面上共价接枝，以改善其血液相位性。首先，通过丙烯酸和PSF膜表面之间的Friedel-Craft反应获得改性的AA-PSF膜。然后，通过将AA-PSF膜的羧基与SHPC的氨基脱水酰化通过脱水酰化通过脱水酰化来制备改性的SHPCS-AA-PSF膜。 ATR-FTIR和XPS测量证实，-COOH基团和SHPC成功接枝到PSF膜的表面上。与原始PSF膜（341μgcm〜（α2））相比，改性的PSF膜显示抑制血小板粘附和低蛋白质吸附（161μgcm〜（β2））。血液化测试表明，改性膜材料具有延长的凝血时间，血浆重新计算时间（PRT），活化的部分血栓形成素时间（APTT），凝血酶时间（TT）和凝血酶原时间（PT）。所有这些结果表明，用丙烯酸和SHPC的PSF膜的表面改性具有良好的血液相色和抗凝血性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号