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首页> 外文期刊>RSC Advances >Cobalt ferrite supported on reduced graphene oxide as a T2 contrast agent for magnetic resonance imaging
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Cobalt ferrite supported on reduced graphene oxide as a T2 contrast agent for magnetic resonance imaging

机译：作为磁共振成像的T2造影剂，将钴铁氧体负载在磁共振成像的T2造影剂上负载

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Nanoscaled spinel-structured ferrites bear promise as next-generation contrast agents for magnetic resonance imaging. However, the small size of the particles commonly leads to colloidal instability under physiological conditions. To circumvent this problem, supports onto which the dispersed nanoparticles can be anchored have been proposed. Amongst these, flakes of graphene have shown interesting performance but it remains unknown if and how their surface texture and chemistry affect the magnetic properties and relaxation time ( T _(2) ) of the ferrite nanoparticles. Here, it is shown that the type of graphene oxide (GO) precursor, used to make composites of cobalt ferrite (CoFe _(2) O _(4) ) and reduced GO, influences greatly not just the T _(2) but also the average size, dispersion and magnetic behaviour of the grafted nanoparticles. Accordingly, and without compromising biocompatibility, a judicious choice of the initial GO precursor can result in the doubling of the proton relaxivity rate in this system.
机译：纳米级尖晶石结构的铁氧体承诺作为用于磁共振成像的下一代对比剂。然而，小尺寸的颗粒通常导致生理条件下的胶体不稳定性。为了避免这种问题，已经提出了分散的纳米颗粒可以抵锚的支撑。其中，石墨烯的剥落表现出有趣的性能，但如果它们的表面纹理和化学的磁性和弛豫时间（T _（2））仍然是未知的，但其仍然是未知的。这里，显示石墨烯（GO）前体的类型，用于制备钴铁氧体的复合材料（CoFe _（2）O _（4））并减少了Go，极大地影响T _（2）但是也是接枝纳米粒子的平均尺寸，分散和磁性。因此，并且在不影响生物相容性的情况下，初始去前体的明智选择可以导致该系统中的质子松弛率的加倍。

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