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首页> 外文期刊>RSC Advances >Non-thermal plasma assisted surface nano-textured carboxymethyl guar gum/chitosan hydrogels for biomedical applications
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Non-thermal plasma assisted surface nano-textured carboxymethyl guar gum/chitosan hydrogels for biomedical applications

机译：用于生物医学应用的非热等离子体辅助表面纳米织地不易羧甲基瓜尔胶/壳聚糖水凝胶

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Smart hydrogels comprising carboxymethyl guar gum and chitosan (CMGG/CS) have been fabricated using tetraethyl orthosilicate as the crosslinker. To render the hydrogels an improved biological efficacy, non-thermal plasma assisted surface modification have been performed using Ar, O _(2) and a mixture of Ar and O _(2) gases. Enhanced surface wettability was witnessed post-plasma treatment. AFM analyses revealed the topographical changes of the hydrogels at the nano-scale level without any adverse effect on their bulk physical structure. The hydrogels exhibited pH-responsive swelling with maximum swelling in neutral pH. The release of diclofenac sodium from the hydrogels confirmed their potential towards colon-targeted drug delivery. Excellent biofilm eradication features against E. coli was demonstrated by the hydrogels. Hemolytic assay on human RBCs affirmed their hemocompatibility. Moreover, the hydrogels were found to be remarkably biodegradable. Thus, non-thermal plasma assisted surface nano-textured CMGG/CS hydrogels can be efficaciously explored for their diverse applications in biomedicine.
机译：使用羧甲基瓜尔胶和壳聚糖（CMGG / CS）的智能水凝胶使用作为交联剂的四乙基硅酸盐制造。为了使水凝胶改善的生物学效果，使用Ar，O _（2）和Ar和O _（2）气体的混合物进行非热血浆辅助表面改性。等离子体处理后，可提高表面润湿性。 AFM分析揭示了纳米级水平的水凝块的地形变化，而不是对散装物理结构的任何不利影响。水凝胶表现出pH响应肿胀，中性pH中最大溶胀。来自水凝胶的双氯芬酸钠的释放证实了它们对靶向靶向药物递送的潜力。水凝胶证明了对大肠杆菌的优异生物膜消除特征。人类RBC上的溶血性测定肯定了它们的血液相位力。此外，发现水凝胶非常可生物降解。因此，可以在生物医学中的各种应用中探索非热等离子体辅助表面纳米纹理CMGG / CS水凝胶。

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