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首页> 外文期刊>RSC Advances >A targeted biocompatible organic nanoprobe for photoacoustic and near-infrared-II fluorescence imaging in living mice
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A targeted biocompatible organic nanoprobe for photoacoustic and near-infrared-II fluorescence imaging in living mice

机译：用于活着小鼠的光声和近红外-II荧光成像的靶向生物相容性有机纳米孔

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Multimodal molecular imaging probes have attracted much attention, and they possess great potential to accurately diagnose diseases due to the synergistic superiorities of multiple complementary imaging. Herein, a targeted biocompatible organic nanoplatform (IR-PEG-FA) with a strong optical absorption in the near-infrared window (NIR-I) for photoacoustic imaging (PAI) and excellent second near-infrared (NIR-II) fluorescence imaging property for NIR-II imaging is fabricated. The dual-modal nanoprobe is composed of the small organic dye molecule IR-1061, water-soluble poly(ethylene glycol) (PEG) and folic acid (FA) as the targeted ligands. Depending on the strength of high temporal resolution and preeminent spatial resolution, the targeted biocompatible dual-mode nanoprobe for PAI and NIR-II imaging can provide more detailed date of cancers and diseases, and enables us to specifically diagnose them through quite a precise way.
机译：多式联运分子成像探针引起了很多关注，并且由于多重互补成像的协同优势，它们具有巨大的诊断疾病的潜力。这里，具有近红外窗口（NIR-I）的具有强光学吸收的靶向生物相容性有机纳米片（IR-PEG-FA），用于光声成像（PAI）和优异的第二近红外（NIR-II）荧光成像性能对于制造NIR-II成像。双模型纳米孔由小有机染料分子IR-1061，水溶性聚（乙二醇）（PEG）和叶酸（FA）作为靶向配体组成。根据高时间分辨率和卓越空间分辨率的强度，PAI和NIR-II成像的目标生物相容性双模纳米孔可以提供更详细的癌症和疾病的日期，并使我们能够通过相当精确的方式专门诊断它们。

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