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首页> 外文期刊>RSC Advances >Synthesis of crosslinkable diblock terpolymers PDPA-b-P(NMS-co-OEG) and preparation of shell-crosslinked pH/redox-dual responsive micelles as smart nanomaterials
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Synthesis of crosslinkable diblock terpolymers PDPA-b-P(NMS-co-OEG) and preparation of shell-crosslinked pH/redox-dual responsive micelles as smart nanomaterials

机译：可交联二嵌段三元共聚物PDPA-B-P（NMS-CO-OEG）的合成及其制备壳交联的pH /氧化还原 - 双响应胶束作为智能纳米材料

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Crosslinked polymer nanomaterials have attracted great attention due to their stability and highly controllable drug delivery; herein, a series of well-defined amphiphilic PDPA- b -P(NMS- co -OEG) diblock terpolymers (P1–P3) were designed and prepared via RAFT polymerization and were self-assembled into non-cross-linked (NCL) nanomicelles, which were further prepared into shell-cross-linked (SCL) micelles via cystamine-based in situ shell cross-linking. Using P3 as an optimized polymer, SCL-P3 micelles were prepared, which demonstrated remarkable pH/redox-dual responsive behaviour. For drug delivery, camptothecin (CPT)-loaded SCL-P3 micelles were prepared and showed much higher CPT-loading capability than their NCL-P3 counterparts. Notably, the SCL-P3 micelles showed good synergistic pH/redox-dual responsive CPT release properties, making them potential “smart” nanocarriers for drug delivery.
机译：由于其稳定性和高度可控的药物递送，交联聚合物纳米材料引起了极大的关注;在此，通过筏聚合设计并制备了一系列良好定义的两亲性PDPA-B-B（NMS-CO-COEG）二嵌段三元共聚物（P1-P3），并将自组装成非交联（NCL）纳米核，通过基于胱胺的原位壳交联，进一步制备成壳交联（SCL）胶束。使用P3作为优化的聚合物，制备SCL-P3胶束，其展示了显着的pH /氧化还原 - 双响应性行为。对于药物递送，制备喜树碱（CPT）加载的SCL-P3胶束并显示比其NCL-P3对应物更高的CPT负载能力。值得注意的是，SCL-P3胶束显示出良好的协同pH /氧化还原 - 双响应性CPT释放性能，使其成为药物递送的潜在“智能”纳米载体。

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