• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>RSC Advances >Theranostic system for ratiometric fluorescence monitoring of peptide-guided targeted drug delivery
【24h】

Theranostic system for ratiometric fluorescence monitoring of peptide-guided targeted drug delivery

机译：用于肽导向靶向药物递送的比例荧光监测的治疗系统

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Conjugation of an anticancer drug with a cancer-specific carrier and a fluorescent dye to form a theranostic system enables real time monitoring of targeted drug delivery (TDD). However, the fluorescence signal from the dye is affected by the light absorption and scattering in the body, photobleaching, and instrumental parameters. Ratiometric measurements utilizing two fluorescence signals of different wavelengths are known to improve sensitivity, reliability and quantitation of fluorescence measurements in biological media. Herein, a novel theranostic system comprising the anticancer drug chlorambucil ( CLB ), cancer-specific peptide octreotide amide ( OctA ), and a long-wavelength dual fluorescent cyanine dye IRD enabling ratiometric monitoring of drug delivery was developed and evaluated on the cancer cell line PANC-1.
机译：抗癌药与癌症特异性载体和荧光染料的缀合以形成治疗系统，可以实时监测靶向药物递送（TDD）。然而，来自染料的荧光信号受到体内的光吸收和散射的影响，光漂白和仪器参数。已知利用两种不同波长的荧光信号的比率测量来提高生物介质中荧光测量的敏感性，可靠性和定量。在此，在癌细胞系上开发并评估了包含抗癌药物氯镁（CLB），癌细胞特异性肽奥胺酰胺（OctA）和长波长双荧光花青染料IRD，并评估癌细胞系（CLB）和长波长双荧光花青醇染料IRD。 Panc-1。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号