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首页> 外文期刊>RSC Advances >Novel biodegradable and non-fouling systems for controlled-release based on poly(ε-caprolactone)/Quercetin blends and biomimetic bacterial S-layer coatings
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Novel biodegradable and non-fouling systems for controlled-release based on poly(ε-caprolactone)/Quercetin blends and biomimetic bacterial S-layer coatings

机译：基于聚（ε-己内酯）/槲皮素共混物和仿生细菌S层涂层的新型生物降解和非污染系统

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Quercetin is a strong antioxidant with low bioavailability due to its high crystallinity. A further drawback is that Quercetin has potentially toxic effects at high concentrations. To improve this low water solubility, as well as control the concentration of the flavonoid in the body, Quercetin is incorporated into a polymeric matrix to form an amorphous solid dispersion (ASD) stable enough to resist the recrystallization of the drug. For this purpose, miscible poly(ε-caprolactone) (PCL) and Quercetin (Q) blends are prepared, provided that they have complementary interacting groups. For compositions in which the flavonoid remains in an amorphous state thanks to the interactions with polymer chains, various PCL/Q drug release platforms are fabricated: micrometric films by solvent casting, nanometric films by spin coating, and nanofibers by electrospinning. Then, the potential use of bacterial S-layer proteins as release-preventive membranes is tested on PCL–Quercetin blends, due to their ability to construct a biomimetic coating including nanometric pores. For all the platforms, the SbpA coating can maintain a stable release under the toxicity level of Quercetin. Accordingly, a PCL/Q system with an S-layer coating allows the design of versatile bioavailable Quercetin eluting devices that prevent toxicity and biofouling issues.
机译：槲皮素是一种强抗氧化剂，具有较低的生物利用度，由于其高结晶度。进一步的缺点是槲皮素在高浓度下具有潜在的毒性作用。为了改善这种低水溶性，除了对体中的黄酮类化合物的浓度，槲皮素被掺入聚合物基质中以形成足以稳定的无定形固体分散体（ASD）以抵抗药物的重结晶。为此目的，制备混溶性聚（ε-己内酯）（PCL）和槲皮素（Q）共混物，条件是它们具有互补的相互作用基团。对于与聚合物链的相互作用的组合物，由于与聚合物链的相互作用，类黄酮留下的组合物，通过溶剂浇铸，通过旋涂，通过静电纺丝通过溶剂铸件，纳米薄膜和纳米纤维来制造各种PCL / Q药物释放平台。然后，由于其构建诸如纳米孔的仿生涂层的能力，在PCL-槲皮素共混物上测试细菌S层蛋白作为释放预防性膜的潜在使用。对于所有平台，SBPA涂层可以在槲皮素的毒性水平下保持稳定的释放。因此，具有S层涂层的PCL / Q系统允许设计用于防止毒性和生物污垢问题的多功能生物可利用的槲皮素洗脱装置。

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