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首页> 外文期刊>RSC Advances >Sandwich-structure hydrogels implement on-demand release of multiple therapeutic drugs for infected wounds
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Sandwich-structure hydrogels implement on-demand release of multiple therapeutic drugs for infected wounds

机译：夹心结构水凝胶为受感染的伤口实施多种治疗药物的按需释放

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Wound infections bring huge challenges to clinical practice. A series of approaches are involved in the management of infected wounds including use of antibacterial agents, granulation tissue regeneration and scar prevention. In this study, we fabricated a sandwich-structure hydrogel dressing through layer-by-layer assembly of films and hydrogels. By pre-loading silver nanoparticles (AgNPs), vascular endothelial growth factors (VEGF) and ginsenoside Rg3 (Rg3) into each layer of the sandwich compound, this hydrogel could realize the sequential release of these drugs onto infected wound beds as demanded. Moreover, altering the thickness of middle layer could further change the drug delivery patterns characterized by delay at the initial releasing timepoint. When applying this dressing on infected wounds of rabbit ears, we found it could alleviate infection-induced inflammation, promote granulation tissue regeneration and inhibit scar formation. Collectively, the design of sandwich-structure hydrogels was facilitated to deliver specific drugs sequentially during their therapeutic time window for complicated diseases and has shown potential applications in infected wounds.
机译：伤口感染带来了临床实践的巨大挑战。一系列方法参与感染伤口的管理，包括使用抗菌剂，造粒组织再生和瘢痕预防。在这项研究中，我们通过薄膜和水凝胶层的层组装制成夹层结构水凝胶敷料。通过将银纳米颗粒（AgNP），血管内皮生长因子（VEGF）和人参皂苷RG3（RG3）加载到夹层化合物中的每层中，该水凝胶可以根据要求将这些药物的连续释放到受感染的伤口床上。此外，改变中间层的厚度可以进一步改变以初始释放时间点延迟表征的药物输送模式。在将这种敷料施加到兔耳的感染伤口时，我们发现它可以缓解感染诱导的炎症，促进肉芽组织再生并抑制瘢痕形成。共同地，促进了夹层结构水凝胶的设计，以在其治疗时间窗口中顺序递送特异性药物，用于复杂的疾病，并在感染的伤口中显示出潜在的应用。

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