• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>RSC Advances >Solvothermal synthesis and modification of NaYF4:Yb/Er@NaLuF4:Yb for enhanced up-conversion luminescence for bioimaging
【24h】

Solvothermal synthesis and modification of NaYF4:Yb/Er@NaLuF4:Yb for enhanced up-conversion luminescence for bioimaging

机译：NayF4：Yb / ER @ NALUF4：Yb用于增强的上转换发光的溶剂，用于增强

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Water-soluble NaYF _(4) :Yb/Er@NaLuF _(4) :Yb up-converting nanoparticles (UCNPs) with a strong green emission were successfully prepared by a solvothermal method in a short period of time and at a low temperature. First, the hydrophobic UCNPs were prepared by a simple solvothermal method, then modified using a polyetherimide (PEI) surfactant or oxidation of the oleic acid ligands with the Lemieux-von Rudloff reagent. The modified UCNPs, having an average particle diameter of 60 ± 5 nm, showed a high dispersity. The oleic acid ligand on the sample surface was oxidized azelaic acid (HOOC(CH _(2) ) _(7) COOH), identified from Fourier transform infrared (FTIR) spectroscopy, which results in the generation of free carboxylic acid, hence conferring a high solubility in water. The 3-4,5-dimethylthiazol-2-yl-2,5-diphenyl tetrazolium bromide (MTT) method and cell-targeted labeling proved that oleic acid-capped UCNPs after oxidation (UCNPs-OAO) have a higher biocompatibility than polyetherimide-capped UCNPs (UCNPs-PEI). Therefore, the UCNPs-OAO have a great potential in biomedical applications, such as multimodal imaging, targeted therapy, and gene therapy.
机译：水溶性Nayf _（4）：Yb / ER @ Naluf _（4）：在短时间内通过溶剂热法在短时间内成功制备具有强大的绿色发射的Yb上转换纳米颗粒（UCNP） 。首先，通过简单的溶剂热法制备疏水性UCNP，然后使用聚醚酰亚胺（PEI）表面活性剂或用LEMIEUX-VON Rudloff试剂进行油酸配体的氧化。平均粒径为60±5nm的改性UCNP显示出高分子。样品表面上的油酸配体被氧化壬二酸（HOOC（CH _（2））_（7）COOH），从傅里叶变换红外（FTIR）光谱产生，这导致产生游离羧酸，因此赋予水中的高溶解度。 3-4,5-二甲基噻唑-2-基2,5-二苯基四唑溴（MTT）方法和细胞靶向标记证明了氧化后的油酸 - 封端的UCNP（UCNPS-OAO）具有比聚醚酰亚胺更高的生物相容性 - 封闭UCNPS（UCNPS-PEI）。因此，UCNPS-OAO在生物医学应用中具有很大的潜力，例如多模式成像，靶向治疗和基因治疗。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号