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首页> 外文期刊>RSC Advances >High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
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High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus

机译：巯基乙烷磺酸官能团官能化TE / BSA纳米蛋白酶对抗动脉病毒和冠状病毒的高抗病毒活性

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摘要

Heparan sulfate (HS) is a kind of cellular adhesion receptor that mediates the attachment and internalization of virus infection. Herein, to mimic the cell surface receptor, mercaptoethane sulfonate (MES), an analogue of HS, was used as the surface modifier to synthesize bovine serum albumin (BSA)-coated tellurium nanoparticles (Te/BSA NPs) with a unique triangular star shape (Te/BSA nanostars). Using porcine reproductive and respiratory syndrome virus (PRRSV), which utilizes HS as a cellular receptor, as a model of arterivirus, we found that Te/BSA nanostars suppressed virus infection mainly by inhibiting the virus internalization process. Interestingly, Te/BSA nanostars exhibited much higher antiviral activity than the spherical Te/BSA NPs (Te/BSA nanospheres), the Te/BSA NPs were synthesized with GSH as a substitute of MES, suggesting that both MES modification and the novel shapes of Te/BSA NPs enhance their antiviral activity. Finally, the antiviral effect of Te/BSA nanostars on porcine epidemic diarrhea virus (PEDV), a model of coronavirus, was also demonstrated, indicating the potential broad-spectrum antiviral property of Te/BSA nanostars.
机译：硫酸乙酰肝素（HS）是一种介导病毒感染的附着和内化的细胞粘附受体。在此，为了模拟细胞表面受体，巯基乙烷磺酸盐（MES），HS的类似物质用作表面改性剂，以合成牛血清白蛋白（BSA）涂覆的碲纳米颗粒（TE / BSA NP），具有独特的三角形星形形状（te / bsa nanostars）。使用猪生殖和呼吸综合征病毒（PRRSV），其利用HS作为细胞受体，作为动脉病毒的模型，我们发现TE / BSA Nanostars主要通过抑制病毒内化过程来抑制病毒感染。有趣的是，TE / BSA Nanostars比球形TE / BSA NPS（TE / BSA纳米球）表现出更高的抗病毒活性，用GSH作为MES的替代品合成TE / BSA NP，表明MES改性和新颖的形状TE / BSA NPS增强其抗病毒活动。最后，还证明了TE / BSA NANOSTARS对猪流行性腹泻病毒（PEDV）的抗病毒作用，表明TE / BSA NANOSTARS的潜在广谱抗病毒性能。

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