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首页> 外文期刊>RSC Advances >A novel cerium(iii)–isatin Schiff base complex: spectrofluorometric and DFT studies and application as a kidney biomarker for ultrasensitive detection of human creatinine
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A novel cerium(iii)–isatin Schiff base complex: spectrofluorometric and DFT studies and application as a kidney biomarker for ultrasensitive detection of human creatinine

机译：一种新型铈（III）-isatin schiff碱基复合体：光谱荧光测定和DFT研究和作为肾脏生物标志物的应用，用于超声检测人体肌酐

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In this paper, a new isatin-Schiff base L1 was prepared via a simple reaction of isatin with 2-amino-3-hydroxypyridin. Subsequently, cerium( III )-Schiff base complex C1 was obtained through the reaction of the prepared Schiff base L1 with cerium chloride via a hydrothermal method. The prepared L1 , as well as C1 , were fully characterized using many spectroscopic techniques, such as mass spectra, elemental analysis, UV-vis, FT-IR, ~(1) H-NMR, ~(13) C-NMR, FE-SEM/EDX, and HR-TEM. A photoluminescence study (PL) was carried out for the prepared complex C1 . The promising photoluminescence results revealed that C1 could be used for the detection of creatinine in different human biological samples as a selective optical biosensor. The results showed that C1 after excitation at 370 nm has a strong emission band at 560 nm. The calibration graph was obtained in a wide concentration range between 2.5 and 480 nM creatinine with limits of detection (LOD) and quantitation (LOQ) of 1.07 and 3.25 nM, respectively. In addition, the correlation coefficient ( r ~(2) ) was found to be 0.9890. The PL spectra indicate that C1 has high selectivity toward creatinine without interference from other different analytes and can be successfully used as an optical sensor for creatinine detection. The mechanism of quenching between the Ce( III ) complex and creatinine was a dynamic type. The geometry of Schiff base L1 and its cerium( III ) complex C1 was proven by using density functional theory (DFT). The energy of the LUMO and HOMO, energy gap, dipole moment and structure–activity relationship were determined and confirmed.
机译：在本文中，通过用2-氨基-3-羟基吡啶蛋白的isatin的简单反应制备了一种新的Isatin-Schiff碱L1。随后，通过通过水热法通过制备的Schiff基碱L1与氯化铈的反应获得铈（III）-Schiff碱基复合物C1。使用许多光谱技术，如质谱，元素分析，UV-Vis，FT-IR，〜（1）H-NMR，〜（13）C-NMR，Fe，所制备的L1和C1完全表征。 -sem / edx和hr-tem。对制备的复合物C1进行光致发光研究（PL）。有前景的光致发光结果表明，C1可用于检测不同人类生物样品中的肌酐作为选择性光学生物传感器。结果表明，370nm在370nm的激发后的C1具有560nm的强发射带。在2.5和480nm肌酐的宽浓度范围内获得校准图，其分别具有1.07和3.25nm的检测（LOD）和定量（LOQ）的限制。此外，发现相关系数（R〜（2））为0.9890。 PL光谱表明C1对肌酐具有高选择性而不会干扰其他不同的分析物，并且可以成功用作用于肌酐检测的光学传感器。 Ce（III）复合物和肌酐之间的淬火机制是动态类型。通过使用密度泛函理论（DFT）证明了Schiff基碱L1及其铈（III）复合物C1的几何形状。确定和证实了LUMO和HOMO，能量隙，偶极矩和结构 - 活性关系的能量。

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