• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>RSC Advances >Near-infrared polyfluorene encapsulated in poly(ε-caprolactone) nanoparticles with remarkable large Stokes shift
【24h】

Near-infrared polyfluorene encapsulated in poly(ε-caprolactone) nanoparticles with remarkable large Stokes shift

机译：近红外聚芴包封在聚（ε-己内酯）纳米粒子中，具有显着的大型斯托克斯班次

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Near-infrared (NIR) fluorescent dyes have attracted increasing attention as fluorescent probes in biomedical applications due to their low biological autofluorescence as well as high tissue penetration depth. However, their being hydrophobic in nature limits their clinical use as they are prone to aggregate in the physiological environment. Herein, we have designed and synthesized a novel polymeric NIR fluorescent dye and then encapsulated it into a poly(ε-caprolactone) ( PCL ) matrix by way of an emulsion–diffusion technique. The effect of the structure of the surfactant on the nanoparticle properties is investigated. Results show that polymeric surfactant, Kolliphor? P188, allows the formation of a high fluorescence intensity of the nanoparticles with the highest level homogeneity and stability. The synthesized nanoparticles show significant advantages in terms of a remarkable large stokes shift (276 nm) in the aqueous solution and excellent biocompatibility. The fabrication process is not limited to encapsulation of polymeric fluorescent dye. The synthesized NIR polymeric nanoparticles would be potentially applicable for biomedical applications.
机译：近红外（NIR）荧光染料由于其低生物学自发荧光以及高组织穿透深度而引起了生物医学应用中的荧光探针的增加。然而，它们在自然中疏水限制了它们的临床用途，因为它们在生理环境中倾向于聚集。在此，我们已经设计和合成了一种新型聚合物NIR荧光染料，然后通过乳液扩散技术将其包封成聚（ε-己内酯）（PCL）基质。研究了表面活性剂结构对纳米颗粒性质的影响。结果表明，聚合物表面活性剂，kolliphor？ P188，允许形成具有最高水平均匀性和稳定性的纳米颗粒的高荧光强度。合成的纳米颗粒在水溶液中具有显着大的斯托克斯（276nm）的显着大斯托克斯（276nm）的显着优势。制造过程不限于聚合物荧光染料的封装。合成的NIR聚合物纳米颗粒可能适用于生物医学应用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号