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首页> 外文期刊>RSC Advances >Neuroprotective constituents from the aerial parts of Cannabis sativa L. subsp. sativa
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Neuroprotective constituents from the aerial parts of Cannabis sativa L. subsp. sativa

机译：来自Cannabis Sativa L. subsp的空中部位的神经保护成分。苜蓿

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Five new compounds including three new cannabinoids, cannabisativas A–C ( 1–3 ), two new phenolic acids, (7 Z ,9 Z )-cannabiphenolic acid A ( 4 ) and (8 S ,9 Z )-cannabiphenolic acid B ( 5 ), together with twelve known compounds ( 6–17 ), were isolated from the aerial parts of Cannabis sativa L. subsp. sativa . The structures of 1–5 were established on the basis of extensive 1D, 2D NMR and HRESIMS analysis. The absolute configurations were determined by comparison between their experimental and calculated spectra of electronic circular dichroism (ECD) or the modified Mosher's method. The neuroprotective effects of the compounds 1–17 were evaluated on PC 12 cells. Compounds 12 , 13 and 15 showed potential protective effects against H _(2) O _(2) -induced damage.
机译：五种新化合物，包括三种新的大麻素，大麻碱A-C（1-3），两个新的酚酸，（7 Z，9 z） - 丙基哌啶酸A（4）和（8S，9 Z）-Cannabipholic acid B（ 5），与十二次已知的化合物（6-17）一起与大麻苜蓿·亚普的航拍分离。苜蓿。基于广泛的1D，2D NMR和Hresims分析建立1-5的结构。通过对电子圆形二色（ECD）或改进的Mosher方法的实验和计算光谱之间的比较来确定绝对配置。在PC 12细胞中评估化合物1-17的神经保护作用。化合物12,13和15显示潜在的保护作用对H _（2）O _（2）诱导的损伤。

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