Parallel G-quadruplex-mediated protein dimerization and activation

Tuom Tinh Thi Truong; Cuong Cao; Dung Thanh Dang

首页> 外文期刊>RSC Advances >Parallel G-quadruplex-mediated protein dimerization and activation

【24h】

Parallel G-quadruplex-mediated protein dimerization and activation

机译：平行的G-Quadreplex介导的蛋白质二聚化和活化

获取原文

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

We studied parallel G4-mediated protein dimerization and activation by incorporating a RHAU peptide with a fluorescent protein FRET pair CFP/YFP and an apoptotic casp9. Occurrence of energy tranfer (from donor CFP to acceptor YFP) and enhancement of 60-fold cleavage efficiency of casp9 were observed in the presence of parallel G4, which indicated that parallel G4 can induce dimerization and activation of proteins. This novel approach holds a great promise for studying G4-targeting functional dimeric proteins in celllular biology.

机译：通过掺入鲁A肽用荧光蛋白质FRET对CFP / YFP和凋亡CASP9，研究了平行的G4介导的蛋白质二聚化和活化。在平行G4的存在下观察到能量转移（来自供体CFP至受体YFP的助剂YFP）的增强，表明平行G4可以诱导蛋白质的二聚化和活化。这种新颖的方法具有在蜂窝生物学中研究G4靶向功能二聚体蛋白的许多希望。

著录项

来源
《RSC Advances》 |2020年第50期|共4页
作者
Tuom Tinh Thi Truong; Cuong Cao; Dung Thanh Dang;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种
中图分类
关键词

相似文献

外文文献
中文文献
专利

1. Parallel G-quadruplex-mediated protein dimerization and activation [J] . Tuom Tinh Thi Truong, Cuong Cao, Dung Thanh Dang RSC Advances . 2020,第50期

机译：平行的G-Quadreplex介导的蛋白质二聚化和活化
2. ATR activation is regulated by dimerization of ATR activating proteins [J] . Vaughn Thada, David Cortez The Journal of biological chemistry . 2021,第48期

机译：通过ATR活化蛋白的二聚化来调节ATR活化
3. Redox-dependent dimerization of p38α mitogen-activated protein kinase with mitogen-activated protein kinase kinase 3 [J] . Rekha Bassi, Joseph R. Burgoyne, Gian F. DeNicola, The Journal of biological chemistry . 2017,第39期

机译：p38α丝裂原活化蛋白激酶激酶3对氧化还原依赖性二聚化
4. Carboxyl Group Protein Footprinting for Mapping the Dimerization Interface and Phosphorylation-induced Conformational Changes of a Membrane-associated Protein Kinase [C] . Hao Zhang, Wei Shen, Ilan Vidavsky, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2010

机译：羧基蛋白蛋白质覆盖膜相关蛋白激酶的二聚化界面和磷酸化诱导的构象变化
5. The role of dimerization and trimerization in alpha helical membrane protein folding: Insights into receptor activation and viral envelope protein activation. [D] . Matthews, Erin Elizabeth. 2007

机译：二聚化和三聚化在α螺旋膜蛋白折叠中的作用：洞察受体激活和病毒包膜蛋白激活。
6. ATR activation is regulated by dimerization of ATR activating proteins [O] . Vaughn Thada, David Cortez 2021

机译：通过ATR活化蛋白的二聚化来调节ATR活化
7. Parallel G-quadruplex-mediated protein dimerization and activation [O] . Tuom Tinh Thi Truong, Cuong Cao, Dung Thanh Dang 2020

机译：平行的G-Quadreplex介导的蛋白质二聚化和活化

Parallel G-quadruplex-mediated protein dimerization and activation

摘要

著录项

相似文献

相关主题

期刊订阅