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Fabrication of paper microfluidic devices using a toner laser printer

机译：使用碳粉激光打印机的纸张微流体装置的制造

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This paper describes a method to fabricate microfluidic paper-based analytical devices (μPADs) using a toner laser printer. Multiple methods have been reported for the fabrication of μPADs for point-of-care diagnostics and environmental monitoring. Despite successful demonstrations, however, existing fabrication methods depend on particular printers, in-house instruments, and synthetic materials. In particular, recent discontinuation of the solid wax printer has made it difficult to fabricate μPADs with readily available instruments. Herein we reported the fabrication of μPADs using the most widely available type of printer: a toner laser printer. Heating of printed toner at 200 °C allowed the printed toner to reflow, and the spreading of the hydrophobic polymer through the filter paper was characterized. Using the developed μPADs, we conducted model colorimetric assays for glucose and bovine serum albumin (BSA). We found that heating of filter paper at 200 °C for 60 min caused the pyrolysis of cellulose in the paper. The pyrolysis resulted in the formation of aldehydes that could interfere with molecular assays involving redox reactions. To overcome this problem, we confirmed that the removal of the aldehyde could be readily achieved by washing the μPADs with aqueous bleach. Overall, the developed fabrication method should be compatible with most toner laser printers and will make μPADs accessible in resource-limited circumstances.
机译：本文介绍了一种使用调色剂激光打印机制造基于微流体纸的分析装置（μPAD）的方法。据报道，据报道了多种方法用于制备μPAD以进行护理点诊断和环境监测。然而，尽管成功的示范，但现有的制造方法依赖于特定的打印机，内部仪器和合成材料。特别是，最近对固体蜡打印机的停止始于难以使用易于可用的仪器制造μPAD。在此，我们通过最广泛的打印机类型报告了μPAD的制造：调色剂激光打印机。在200℃下加热印刷的调色剂允许印刷的调色剂回流，并且疏水聚合物通过滤纸扩散。使用开发的μPADS，我们对葡萄糖和牛血清白蛋白（BSA）进行了色比生测定。我们发现在200℃下加热滤纸60分钟，导致纸中的纤维素热解。热解导致形成醛，这可能会干扰涉及氧化还原反应的分子测定。为了克服这个问题，我们证实可以通过用水性漂白剂洗涤μPAD来容易地实现醛的除去。总的来说，开发的制造方法应与大多数调色剂激光打印机兼容，并将在资源有限的情况下进行μPAD。

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