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首页> 外文期刊>RSC Advances >Surface coating determines the inflammatory potential of magnetite nanoparticles in murine renal podocytes and mesangial cells
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Surface coating determines the inflammatory potential of magnetite nanoparticles in murine renal podocytes and mesangial cells

机译：表面涂层决定了小鼠肾小珠细胞和梭菌细胞中磁铁矿纳米粒子的炎症潜力

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Drug-induced nephrotoxicity is a frequent adverse event and a dose-limiting factor in patient treatment and is a leading cause of prospective drug attrition during pharmaceutical development. Despite the obvious benefits of nanotherapeutics in healthcare strategies, the clearance of imaging agents and nanocarriers from the body following their therapeutic or diagnostic application generates concerns about their safety for human health. Considering the potency of nanoparticles and their massive utilization in biomedicine the impact of magnetic nanoparticles (MNPs) on cells forming the filtration apparatus of the kidney was studied. Using primary mouse renal glomerular podocytes and mesangial cells, we investigated their response to exposure to magnetic nanoparticles coated with polyethylene glycol and bovine serum albumin. Cultured podocytes were more sensitive to MNPs than mesangial cells displaying signs of cell damage and stronger inflammatory response. Both types of MNPs induced the remodeling of actin fibers, affected the cell shape and triggered expression of inflammatory cytokines TNFα and IL-6 in podocytes. On the other hand, iNOS was induced in both renal cell types but only by MNPs with a polyethylene glycol coating. Our results have revealed that the type of cell and the type of nanoparticle coating might be the strongest determinants of cellular response toward nanoparticle exposure. Differences in susceptibility of cells to MNPs might be evident also between neighboring renal cell subpopulations integrally forming functional sub-units of this organ.
机译：药物诱导的肾毒性是患者治疗中经常不良事件和剂量限制因素，是药物发育期间前瞻性药物疲劳的主要原因。尽管纳米治疗方法在医疗保健策略中有明显的益处，但在治疗或诊断应用后，对身体的成像剂和纳米载体的间隙产生了对人类健康安全的担忧。考虑了纳米颗粒的效力及其在生物医学中的巨大利用率，研究了磁性纳米粒子（MNP）对形成肾脏过滤装置的细胞的影响。使用原发性鼠标肾肾小球大织物和Mesangial细胞，我们研究了对涂有聚乙二醇和牛血清白蛋白涂覆的磁性纳米颗粒的响应。培养的哆粒细胞对MnPs比显示细胞损伤迹象和更强的炎症反应的含义细胞更敏感。两种类型的MNP诱导肌动蛋白纤维的重塑，影响细胞形状并触发炎性细胞因子TNFα和IL-6的表达在多粒细胞中。另一方面，在肾细胞类型中诱导INOS，但仅由MNP与聚乙二醇涂层涂布。我们的结果表明，细胞类型和纳米粒子涂层的类型可能是对纳米粒子暴露的细胞反应的最强的决定因素。在整体形成该器官的功能子单元之间的相邻肾细胞群之间，细胞对MNP的易感性的差异可能是显而易见的。

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