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首页> 外文期刊>RSC Advances >Doxorobicin as cargo in a redox-responsive drug delivery system capped with water dispersible ZnS nanoparticles
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Doxorobicin as cargo in a redox-responsive drug delivery system capped with water dispersible ZnS nanoparticles

机译：Doxorobicin作为货物在氧化还原响应药物递送系统中，用水分散ZnS纳米粒子盖住

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In this work, we have prepared and investigated a redox-responsive drug delivery system (DDS) based on a porous carrier. Doxorubicin (DOX), a chemotherapy medication for treatment of different kinds of cancer, was used as a model drug in the study. DOX was loaded in ordered hexagonal mesoporous silica SBA-15, a nanoporous material with good biocompatibility, stability, large pore size and specific surface area ( S _(BET) = 908 m ~(2) g ~(?1) , V _(P) = 0.79 cm ~(3) g ~(?1) , d = 5.9 nm) and easy surface modification. To prepare the redox-responsive system, cystamine derivative ligands, with redox active disulphide linkers were grafted onto the surface of SBA-15. To ensure no significant premature release of DOX from the porous system, thioglycolic acid modified ZnS nanoparticles (ZnS–COOH NPs) were used as pore capping agents. The grafted redox-responsive cystamine derivative ligand containing disulphide linkers was bonded by a peptide bond to the thioglycolic acid groups of ZnS–COOH NPs, capping the pores. Once the disulphide bond was cleaved, the ZnS–COOH NPs caps were released and pores were opened to deliver the DOX cargo. The dithiol bond was cleavable by redox active molecules such as dithiothreitol (DTT) or glutathione, the concentration of which in cancer cells is 4 times higher than in healthy cells. The redox release of DOX was studied in two different media, physiological saline solution with DTT and saline without DTT. The prepared DDS proved the concept of redox responsive release. All samples were characterised by powder X-ray diffraction (XRD), transition electron microscopy (TEM), nitrogen adsorption/desorption at 77 K, Fourier-transform infrared spectroscopy (FTIR), thermal analysis and zeta potential measurements. The presence of semiconducting ZnS nanoparticle caps on the pore openings was detected by magnetic measurements using SQUID magnetometry showing that such cargo systems could be monitored using magnetic measurements which opens up the possibilities of using such drug delivery systems as theranostic agents.
机译：在这项工作中，我们已经制备并研究了基于多孔载体的氧化还原响应药物输送系统（DDS）。 Doxorubicin（Dox），用于治疗不同种类的癌症的化疗药物，用作研究中的模型药物。 DOX装载在有序的六方介孔硅SBA-15中，纳米多孔材料，具有良好的生物相容性，稳定性，大孔径和比表面积（S _（BET）= 908m〜（2）G〜（α1），v _ （P）= 0.79厘米〜（3）G〜（α1），D = 5.9 nm，易于表面改性。为了制备氧化还原响应系统，将氧化还原活性二硫键连接物嫁接到SBA-15的表面上。为了确保从多孔系统没有明显过早释放DOX，将巯基乙酸改性ZnS纳米颗粒（ZnS-CoOH NPS）用作孔封端剂。将含有二硫化物接头的接枝氧化还原酸敏氧胺衍生物配体通过肽键与ZnS-CoOH NPS的巯基乙酸基团键合，覆盖孔隙。一旦二硫键被切割，释放ZnS-CoOH NPS帽，打开孔以递送DOX货物。通过氧化还原活性分子如二硫醇（DTT）或谷胱甘肽（DTT）或谷胱甘肽的浓度可裂解所述二硫醇键，其浓度比健康细胞高4倍。 DOX的氧化还原释放在两种不同的培养基中，用DTT和盐水没有DTT的生理盐水溶液。准备好的DDS证明了氧化还原响应释放的概念。所有样品的特征在于粉末X射线衍射（XRD），过渡电子显微镜（TEM），77K，傅里叶变换红外光谱（FTIR），热分析和Zeta电位测量。散射电子显微镜（TEM），氮吸附/解吸。通过使用鱿鱼磁度测量法检测孔隙开口上半导体ZnS纳米颗粒帽的存在，示出了可以使用磁性测量监测这种货物系统，这使得使用这种药物输送系统作为治疗剂的可能性。

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