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首页> 外文期刊>RSC Advances >A hybrid lipid membrane coating “shape-locks” silver nanoparticles to prevent surface oxidation and silver ion dissolution
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A hybrid lipid membrane coating “shape-locks” silver nanoparticles to prevent surface oxidation and silver ion dissolution

机译：杂交脂膜涂层“形状锁”银纳米颗粒，以防止表面氧化和银离子溶解

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The controlled synthesis of stable silver nanoparticles (AgNPs), that do not undergo surface oxidation and Ag ~(+) ion dissolution, continues to be a major challenge. Here the synthesis of robust hybrid lipid-coated AgNPs, comprised of L -α-phosphatidylcholine (PC) membranes anchored by a stoichiometric amount of long-chained hydrophobic thiols and sodium oleate (SOA) as hydrophobic binding partners, that do not undergo surface oxidation and Ag ~(+) ion dissolution, is described. UV-Visible (UV-Vis) spectroscopy, transmission electron microscopy (TEM), and inductively coupled plasma mass spectrometry (ICP-MS) demonstrate that in the presence of strong oxidants, such as potassium cyanide (KCN), the hybrid lipid-coated AgNPs are stable and do not undergo surface oxidation even in the presence of membrane destabilizing surfactants. UV-Vis studies show that the stability of hybrid lipid-coated AgNPs of various sizes and shapes is dependent on the length of the thiol hydrocarbon chain and can be ranked in the order of increasing stability as follows: propanethiol (PT) < hexanethiol (HT) ≤ decanethiol (DT). UV-Vis and ICP-MS studies show that the hybrid lipid-coated AgNPs do not change in size or shape confirming that the AgNPs do not undergo surface oxidation and Ag ~(+) ion dissolution when placed in the presence of strong oxidants, chlorides, thiols, and low pH. Long-term stability studies, over 21 days, show that the hybrid lipid-coated AgNPs do not release Ag ~(+) ions and are more stable. Overall, these studies demonstrate hybrid membrane encapsulation of nanomaterials is a viable method for stabilizing AgNPs in a “shape-locked” form that is unable to undergo surface oxidation, Ag ~(+) ion release, aging, or shape conversion. More importantly, this design strategy is a simple approach to the synthesis and stabilization of AgNPs for a variety of biomedical and commercial applications where Ag ~(+) ion release and toxicity is a concern. With robust and shielded AgNPs, investigators can now evaluate and correlate how the physical features of AgNPs influence toxicity without the confounding factor of Ag ~(+) ions present in samples. This design strategy also provides an opportunity where the membrane composition can be tuned to control the release rate of Ag ~(+) ions for optimizing antimicrobial activity.
机译：不经历表面氧化和Ag〜（+）离子溶解的稳定银纳米颗粒（AgNP）的控制合成仍然是一个主要挑战。在这里，由由化学计量的长链疏水硫醇和油酸钠（SOA）固定的L-α-磷脂基胆碱（PC）膜组成的鲁棒杂化脂质涂覆的AgNPS作为疏水的结合伴侣，其不受表面氧化和Ag〜（+）离子溶解描述。 UV可见（UV-VIS）光谱，透射电子显微镜（TEM）和电感耦合等离子体质谱（ICP-MS）表明，在存在强氧化剂的情况下，例如氰化钾（KCN），杂化脂质涂覆即使在膜不稳定表面活性剂存在下，AgNP也稳定，也不会发生表面氧化。 UV-Vis研究表明，各种尺寸和形状的杂化脂质涂覆的AgNP的稳定性取决于硫醇烃链的长度，并且可以按照稳定性的阶数排序，如下：丙硫醇（Pt）<六烷醇（HT ）≤癸硫醇（DT）。 UV-Vis和ICP-MS研究表明，杂化脂质涂覆的agnps不改变尺寸或形状，确认在置于强氧化剂，氯化物存在下时，AgNP不会经历表面氧化和Ag〜（+）离子溶解，硫醇和低pH值。长期稳定性研究，超过21天，表明杂化脂质涂覆的agnps不释放Ag〜（+）离子并且更稳定。总体而言，这些研究表明纳米材料的杂化膜包封是一种可行的方法，用于以“形状锁定的”形式稳定AgNP的可行方法，该形式不能经历表面氧化，Ag〜（+）离子释放，老化或形状转化。更重要的是，这种设计策略是一种简单的方法，用于合成和稳定AgNP的各种生物医学和商业应用，其中Ag〜（+）离子释放和毒性是一个问题。具有稳健和屏蔽的agnps，研究者现在可以评估和关联AgNPS影响毒性的物理特征，而不是样品中存在的Ag〜（+）离子的混淆因子。这种设计策略还提供了可以调节膜组合物以控制Ag〜（+）离子的释放速率优化抗微生物活性的机会。

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