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首页> 外文期刊>RSC Advances >Strategy to design a smart photocleavable and pH sensitive chitosan based hydrogel through a novel crosslinker: a potential vehicle for controlled drug delivery
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Strategy to design a smart photocleavable and pH sensitive chitosan based hydrogel through a novel crosslinker: a potential vehicle for controlled drug delivery

机译：通过新型交联剂设计智能光纤维和pH敏感壳聚糖水凝胶的策略：控制药物递送的潜在载体

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摘要

We report herein the synthesis of a novel photocleavable crosslinker, 4-formylphenyl 4-((4-formylphenoxy)methyl)-3-nitrobenzoate (CHO–ONB–CHO) and its joining with amine-based polysaccharides, viz . chitosan, resulting in the formation of a dual stimuli-responsive (ONB–chitosan) hydrogel having UV- and pH-responsive sites. The detailed mechanism for the formation of CHO–ONB–CHO and ONB–chitosan hydrogel is proposed. The (CHO–ONB–CHO) crosslinker was characterized using ~(1) H-NMR, LCMS and UV-visible spectroscopy. The dual responsive hydrogel is characterized by FTIR, SEM, XRD, DSC and TGA. The crosslinked hydrogel displayed mechanical robustness with a storage modulus of about 1741 pa. The pH-responsiveness of the hydrogel was studied via equilibrium swelling studies in various pH media at 37 °C. The photocleavable behavior of the crosslinker was observed in the UV-absorption range of 310–340 nm and the hydrogel exhibited maximum swelling at pH 5.7. The higher swelling of the hydrogel in acidic conditions and its photo-responsiveness can be exploited for the controlled, temporal and spatial release of therapeutic drugs at any inflammatory areas with acidic environments. It was observed that the hydrogel exhibited higher drug release at pH 5.7 than at pH 7.4.
机译：我们在本文中报告了一种新型光纤维可爱交联剂，4-甲酰苯基4-（（4-甲酰苯氧基）甲基）-3-硝基苯甲酸甲酯（CHO-ONB-CHO）及其与胺类多糖的连接和加入。壳聚糖，导致形成具有UV和pH-响应位点的双刺激响应（ONB-Chitosan）水凝胶。提出了Cho-Onb-cho和甲壳豆水凝胶形成的详细机制。 （CHO-ONB-CHO）交联剂的特征在于使用〜（1）H-NMR，LCMS和UV可见光谱。双敏感水凝胶的特征在于FTIR，SEM，XRD，DSC和TGA。交联水凝胶显示出具有约1741Pa的储存模量的机械稳健性。通过在37℃下通过各种pH培养基中的平衡溶胀研究研究了水凝胶的pH-反应性。在310-340nm的UV吸收范围内观察到交联剂的光纤维可变行为，水凝胶在pH5.7下表现出最大溶胀。水凝胶在酸性条件下的较高溶胀及其光响应性可以用于酸性环境的任何炎症区域的治疗药物的受控，时间和空间释放。观察到水凝胶在pH5.7下表现出高于pH7.4的较高药物释放。

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