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Synthesis and application of coumarin fluorescence probes

机译:香豆素荧光探针的合成与应用

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In recent years, the research on fluorescent probes has developed rapidly. Coumarin fluorescent probes have also been one of the hot topics in recent years. For the synthesis and application of coumarin fluorescent probes, great progress has been made. Coumarin fluorescent probes have become more and more widely used in biochemistry, environmental protection, and disease prevention, and have broad prospects. This review introduces the three main light emitting mechanisms (PET, ICT, FRET) of fluorescent probes, and enumerates some probes based on this light emitting mechanism. In terms of the synthesis of coumarin fluorescent probes, the existing substituents on the core of coumarin compounds were modified. Based on the positions of the modified substituents, some of the fluorescent probes reported in the past ten years are listed. Most of the fluorescent probes are formed by modifying the 3 and 7 position substituents on the mother nucleus, and the 4 and 8 position substituents are relatively less modified. In terms of probe applications, the detection and application of coumarin fluorescent probes for Cu ~(2+) , Hg ~(2+) , Mg ~(2+) , Zn ~(2+) , pH, environmental polarity, and active oxygen and sulfide in the past ten years are mainly introduced.
机译:近年来,荧光探头的研究迅速发展。香豆素荧光探针近年来也是热门话题之一。对于香豆素荧光探针的合成和应用,已经取得了巨大进展。香豆素荧光探针已经变得越来越广泛地用于生物化学,环保和疾病预防,并具有广阔的前景。本综述介绍了荧光探针的三个主要发光机制(PET,ICT,FRET),并根据该发光机制来列举一些探针。就香豆素荧光探针的合成而言,修饰了香豆素化合物的核心上的现有取代基。基于改性取代基的位置,上市过去十年报告的一些荧光探针。大多数荧光探针通过在母细胞核上改变3和7个位置取代基来形成,并且4和8个位置取代基被相对较低。在探针应用方面,Cumarin荧光探针对Cu〜(2+),Hg〜(2+),mg〜(2+),Zn〜(2+),pH,环境极性和活性的检测和应用主要介绍了过去十年的氧气和硫化物。

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