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首页> 外文期刊>RSC Advances >Highly rapid and non-enzymatic detection of cholesterol based on carbon nitride quantum dots as fluorescent nanoprobes
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Highly rapid and non-enzymatic detection of cholesterol based on carbon nitride quantum dots as fluorescent nanoprobes

机译：基于氮化碳量子点作为荧光纳米体的高度快速和非酶促检测胆固醇

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In this work, we reported a highly rapid and non-enzymatic method for cholesterol measuring based on carbon nitride quantum dots (CNQDs) as fluorescent nanoprobes, which were synthesized through chemical oxidation. The obtained CNQDs displayed high quantum yield up to 35% as well as excellent photostability, water solubility and low toxicity. We found that the fluorescence of CNQDs could be quenched more than 90% within 30 seconds by cholesterol through the formation of hydrogen bonds between –NH _(2) , –NH on the surface of CNQDs and cholesterol containing –OH. According to this phenomenon, a cholesterol detection method was constructed with a wide linear region over the range of 0–500 μmol L ~(?1) and a detection limit as low as 10.93 μmol L ~(?1) , and it possessed the obvious advantages of being a very rapid process and avoiding the use of enzymes. In addition, this method showed high selectivity in the presence of various interfering reagents and applicability to the measurement of cholesterol in fetal bovine serum, which indicated its potential application value in clinical settings.
机译：在这项工作中，我们报道了基于氮化物量子点（CNQDS）作为荧光纳米体的胆固醇测量的高度快速和非酶法，通过化学氧化合成。所得CNQDS显示出高达35％的高量子率，以及优异的光稳定性，水溶解度和低毒性。我们发现，通过在-NH _（2），-NH的表面之间的氢键和含有-OH的胆固醇之间的氢键，通过胆固醇将CNQDS的荧光可以在30秒内超过90％猝灭。根据这种现象，在0-500μmolL〜（α1）范围内的宽线性区域构建胆固醇检测方法，检测极限为低至10.93μmoll〜（？1），并且它具有是一种非常快速的过程和避免使用酶的明显优势。此外，该方法在各种干扰试剂存在下表现出高选择性，并在胎牛血清中测量胆固醇的适用性，这表明其临床环境中的潜在应用价值。

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