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首页> 外文期刊>RSC Advances >The structural composition of components contributes to the superiority of the geoherb Alisma orientale for “diuresis and diffusing dampness”
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The structural composition of components contributes to the superiority of the geoherb Alisma orientale for “diuresis and diffusing dampness”

机译：组件的结构组成有助于“利尿和扩散潮湿”的Geoherb Alisma Orientale的优越性

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The purpose of this study is to explore the intrinsic reasons for the superiority of the salt-made geoherb Alisma orientale via comparing the content of various components of the salt-made geoherb Alisma orientale . The effects of “diuresis and diffusing dampness” using salt-made Alisma orientale from seven different origins were investigated through pharmacodynamic experiments in vivo and in vitro . The results indicated that salt-made Alisma orientale from different origins had diuretic efficacy; this was demonstrated by the significant increase in the volume of rat urine, the concentration of Na ~(+) , K ~(+) , and Cl ~(?) in the urine, and the significant decrease in the levels of AQP-2 in rat renal medulla and HK-2 cells. It was also revealed that the diuretic effect of salt-made Alisma orientale from Fujian Province is stronger than those from other provinces. Moreover, the main components and their proportions in the salt-made Alisma orientale samples were further analyzed via principal component analysis. The results showed that alisol A 24-acetate, alisol B, and 23-acetyl alisol B are the main components of salt-made Alisma orientale , and the optimal structural ratio of alisol A 24-acetate, alisol B, and 23-acetyl alisol B was found to be 5.38?:?14.34?:?11.31 via optimizing the ratios of the three main components. It is worth noting that the optimal ratio of the three main components after optimization is the closest to the ratio of the three main components in salt-made Alisma orientale from Fujian Province. This paper reveals the “mystery” of the content ratio of the main active components and its effect on the efficacy, and showed that the proportional relationship between the content of multiple components is the key to their interactions. Therefore, this method of evaluating the quality of salt-made Alisma orientale is obviously reliable, and this study lays the foundations for quality evaluation of salt-made Alisma orientale and other herb slices.
机译：本研究的目的是探讨通过比较盐制造的Geoherb Alisma Orientale的各种组分的含量来探讨盐制造的Geoherb Alisma Orientale的优越性的内在原因。通过体内和体外的药物动力学实验研究了使用七种不同起源的盐制成的Alisma Orientale的“利尿和扩散湿度”的影响。结果表明，来自不同起源的盐制成的Alisma Orientale具有利尿功效;这是通过大鼠尿体积的显着增加，尿液中Na〜（+），K〜（+）和Cl〜（？）的显着增加，以及AQP-2水平的显着降低在大鼠肾髓质和HK-2细胞中。还有人透露，福建省盐制造的Alisma Orientale的利尿作用比来自其他省份的利用效果强。此外，通过主要成分分析进一步分析了盐制铝化型铝化铝化样品中的主要成分及其比例。结果表明，Alisol A 24-乙酸盐，alisol B和23-乙酰alisolb是盐制铝化型甲状腺肿的主要成分，以及Alisol A 24-乙酸盐，alisol B和23-乙酰alisol的最佳结构比B被发现为5.38？：？14.34？：？11.31通过优化三个主要成分的比率。值得注意的是，优化后三种主要成分的最佳比率最接近福建省盐制造的Alisma Orientale中的三个主要成分的比例。本文揭示了主要活性成分的内容比的“神秘”及其对疗效的影响，并表明多个组分含量与其相互作用的关键。因此，这种评估盐制造的Alisma Orientale品质的方法显然是可靠的，这项研究奠定了盐成的Alisma Orientale和其他草本切片的质量评估基础。

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