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A novel surface-enhanced Raman scattering method for simultaneous detection of ketamine and amphetamine

机译：一种新型表面增强拉曼散射方法，用于同时检测氯胺酮和amphetamine

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摘要

As common psychotropic drugs, ketamine (KET) and amphetamine (AMP) are often consumed by drug users at the same time, which seriously threatens people's health. Therefore, the study of simultaneous detection methods for KET and AMP is imperative. In this study, a novel method for the simultaneous detection of KET and AMP in serum was established on the basis of surface-enhanced Raman scattering (SERS). The antibodies were attached on Au@Ag core–shell nanoparticles embedded with different Raman reporters as the detection substrates. The labelled antigens KET–BSA and AMP–BSA were linked to carboxyl magnetic beads, and by adopting the principle of competitive immunoassay, the quantitative detections of ketamine and amphetamine were realized at the same time by detecting the Raman signals at different characteristic peaks on the magnetic beads. A good correlation was shown between ketamine and amphetamine and Raman signal response values were in the concentration range of 0–60 ng mL ~(?1) and 0–200 ng mL ~(?1) , and the limits of detection were 1.64 and 2.44 ng mL ~(?1) . This method had the advantages of simple, rapid operation, and high sensitivity, and can realise double indicator simultaneous detection, which provided a more favorable scientific basis for preventing or reducing drug abuse, and identifying and monitoring drug users.
机译：作为常见的精神药物，氯胺酮（KET）和Amphetamine（AMP）通常同时用吸毒者消耗，这严重威胁着人们的健康。因此，对KET和AMP的同时检测方法的研究是势不一准的。在该研究中，基于表面增强的拉曼散射（SERS）建立了一种同时检测KET和AMP的新方法。将抗体连接在嵌入不同拉曼记者的Au @ Ag核 - 壳纳米粒子上作为检测基板。标记的抗原KET-BSA和AMP-BSA与羧基磁珠连接，采用竞争性免疫测定的原理，通过检测不同特征峰的拉曼信号，同时实现氯胺酮和苯丙胺的定量检测磁珠。在氯胺酮和安非胺之间显示出良好的相关性，拉曼信号响应值在0-60ng ml〜（α1）和0-200ng ml〜（α1）的浓度范围内，检测限为1.64和2.44 ng ml〜（？1）。该方法具有简单，操作快速，灵敏度高的优点，并且可以实现双重指示器同时检测，为预防或减少药物滥用提供更有利的科学依据，并识别和监测吸毒者。

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