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MRI contrast enhancement of liver pre-neoplasia using iron–tannic nanoparticles

机译：使用铁鞣纳米粒子的肝脏预瘤的MRI对比度增强

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摘要

The most challenging part of liver cancer detection is finding it in the very early stages. It has been argued that liver preneoplasia is found at the very earliest stages of liver cancer. The presence of a lesion is closely related to the development of HCC. We report herein a new class of iron-based T _(1) MRI contrast agents which are nanoparticles of iron–tannic complexes (so-called Fe–TA NPs) that can be used for detecting liver preneoplasia. Preliminary assessment of their toxicity in healthy rats provides suitable imaging dose ranges with acceptable toxicity. In diethylnitrosamine (DEN) induced rats, it is shown that Fe–TA NPs are capable of enhancing MRI signals in rat livers having pre-neoplastic lesions within 60 minutes post-injection. The enhancement efficacy is strongly dependent on the characteristics of pre-neoplastic foci (GST-P+ foci). The highest enhancement was in good correlation with the size of GST-P+ foci and amount of Fe–TA NPs accumulated in the liver, and might be caused by the dysfunction of liver sinusoids along with cellular uptake capability of pre-neoplastic hepatocytes. Our results show that Fe–TA NPs are of great interest to develop as an efficient MRI imaging agent for risk assessment of liver cancer.
机译：肝癌检测中最具挑战性的部分是在早期阶段发现它。有人认为，肝脏肾上腺素是在肝癌的最早阶段发现的。病变的存在与HCC的发展密切相关。我们在本文中报告了一种新的铁基T _（1）MRI造影剂，其是铁鞣复合物的纳米颗粒（所谓的Fe-Ta NPS），其可用于检测肝脏preneoplasia。对健康大鼠毒性的初步评估提供了合适的成像剂量范围，具有可接受的毒性。在二乙基腈胺（DEN）诱导的大鼠中，示出了Fe-Ta NPS能够在预注射后60分钟内提高具有预瘤外病变的大鼠肝脏的MRI信号。增强效果强烈依赖于预瘤骨质灶（GST-P +焦点）的特征。最高增强与GST-P +焦点的大小以及肝脏中积累的Fe-Ta NP的量良好，并且可能是由肝脏正弦曲面的功能障碍以及预瘤前肝细胞的细胞摄取能力引起的。我们的研究结果表明，FE-TA NPS具有很大的兴趣，作为肝癌风险评估的有效MRI成像剂。

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