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首页> 外文期刊>RSC Advances >Polymer-supported benzimidazolium based ionic liquid: an efficient and reusable Br?nsted acid catalyst for Biginelli reaction
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Polymer-supported benzimidazolium based ionic liquid: an efficient and reusable Br?nsted acid catalyst for Biginelli reaction

机译：基于聚合物支持的苯并咪唑鎓离子液体：高效可重复使用的BRαnsted酸催化剂用于Biginelli反应

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摘要

A polymer-supported benzimidazolium based ionic liquid (PSBIL) was synthesized by reaction of poly(vinylbenzyl chloride) and benzimidazole followed by ring opening of 1,4-butane sultone and acidification with sulphuric acid. The resulting Br?nsted acid heterogeneous organocatalyst is very competent for the Biginelli reactions under mild conditions in high yields of 3,4-dihydropyrimidine-2(1 H )-one/thiones (DHPMs). Since poly(vinylbenzyl chloride) makes the catalyst bed, the sulphonic acid catalyst will have high loading level of acidic groups compare to other heterogeneous acid catalysts. In spite of conventional heterogeneous ionic liquid catalysts, current PSBIL shows thermal stability up to 334 °C and recyclability up to 5 cycles. This PSBIL signifies a new class of heterogeneous catalyst which is particularly noticeable in green chemistry. The present protocol highlights the easy separation of products without further purification. Furthermore, the effectiveness of this protocol has demonstrated by synthesis of mitotic Kinesin EG5 inhibitor, “Monastrol” under optimized conditions.
机译：通过聚（乙烯基苄基）和苯并咪唑的反应合成聚合物支持的苯并咪唑鎓离子液体（PSBIL），然后用1,4-丁烷磺酸和硫酸酸化的环开口合成。得到的Brα.Nsted酸异质有机催化剂对于在温和条件下的高产率为3,4-二氢嘧啶-2（1H） - ONE / Thiones（DHPMS）下的温和条件下的Biginelli反应非常竞争。由于聚（乙烯基苄基氯）使催化剂床制成催化剂床，因此磺酸催化剂将具有高负荷的酸性基团与其他非均相酸催化剂相比。尽管存在常规的异构离子液体催化剂，但目前的PSBIL显示出高达334℃的热稳定性，可再循环性高达5次循环。该PSBIL表示新类别的异质催化剂，其在绿色化学中特别明显。本协议突出显示产品的易于分离，无需进一步纯化。此外，通过在优化条件下合成有丝分裂kinesin eg5抑制剂，“monastrol”，证明了该方案的有效性。

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