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首页> 外文期刊>RSC Advances >Hematoporphyrin and doxorubicin co-loaded nanomicelles for the reversal of drug resistance in human breast cancer cells by combining sonodynamic therapy and chemotherapy
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Hematoporphyrin and doxorubicin co-loaded nanomicelles for the reversal of drug resistance in human breast cancer cells by combining sonodynamic therapy and chemotherapy

机译：血卟啉和多柔比星共同装载的纳米，用于通过组合肱骨动力学治疗和化疗来逆转人乳腺癌细胞中的耐药性

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摘要

Drug resistance is a main reason for the failure of chemotherapy in cancer treatments. Sonodynamic therapy (SDT) shows great potential for reversing drug resistance of chemotherapy. Here, a sonosensitizer hematoporphyrin (HP) and a chemotherapeutic drug doxorubicin (DOX) were co-loaded into Pluronic F68 nanomicelles for combining SDT and chemotherapy to reverse cancer drug resistance. This multi-functional nanosystem, called HPDF nanomicelle, had a classic “core–shell” structure and a size smaller than 100 nm. In drug-resistant human breast cancer MCF-7/ADR cells that over-express P-glycoprotein (P-gp), HPDF nanomicelles combined with a low-intensity ultrasound could effectively inhibit cell proliferation, promote cell apoptosis and arrest cell cycle at S-phase. Compared free DOX, HPDF nanomicelles significantly reversed drug resistance in MCF-7/ADR cells and the reversal index reached up to 19.0. Apparently, the synergistic effects of combination treatment of SDT and chemotherapy induced by HPDF nanomicelles played important roles in the reversal process against drug resistance. In summary, our study provides a novel strategy for overcoming drug resistance in breast cancer by combining SDT and chemotherapy.
机译：耐药性是癌症治疗中化疗失败的主要原因。 Sonodynamic Therapy（SDT）显示出逆转化疗耐药性的巨大潜力。这里，超声溶胶血管卟啉（HP）和化学治疗药物多柔比星（DOX）被加载到Pluronic F68纳米核细胞中，用于将SDT和化学疗法结合到逆转癌症耐药性。这种称为HPDF Nanomicelle的多功能纳米系统，具有经典的“核心壳”结构，尺寸小于100nm。在耐药性人乳腺癌MCF-7 / ADR细胞中，过表达p-糖蛋白（P-GP），HPDF纳米钙与低强度超声组合可以有效地抑制细胞增殖，促进细胞凋亡并在s中捕获细胞周期-阶段。无比较的DOX，HPDF纳米钙在MCF-7 / ADR细胞中显着逆转耐药性，逆转指数达到高达19.0。显然，HPDF Nanomicelles诱导的SDT和化疗组合治疗的协同效应在抗耐药性反转过程中起重要作用。总之，我们的研究通过结合SDT和化疗，提供了一种克服乳腺癌耐药性的新策略。

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