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首页> 外文期刊>RSC Advances >Soluble silicon patterns and templates: calcium phosphate nanocrystal deposition in collagen type 1
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Soluble silicon patterns and templates: calcium phosphate nanocrystal deposition in collagen type 1

机译：可溶性硅图案和模板：胶原型磷酸钙纳米晶沉积1型

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摘要

Patterned mineralisation is a feature of many hard-tissues. The impressive mechanical properties exhibited by such tissues can be, in part, attributed to the patterned deposition of mineral within the organic matrix. Although not thermodynamically favourable, the deposition of calcium phosphate based mineral within collagen fibres occurs in vivo in bone and dentine. As a consequence, numerous researchers have investigated how matrix proteins may be conditioned to enable patterned mineral deposition to recapitulate the structures found in nature. In this study, we have demonstrated that this patterned mineralisation of collagen type I may be induced simply by the pretreatment of the collagen with orthosilicic acid (OSA). The OSA treatment of the collagen resulted in a structural change to the collagen fibres, modifying the fibril diameter and changing the kinetics of fibre formation. NMR demonstrated that the OSA was preferentially located at the termini of the procollagen fibrils, thereby templating the formation of apatitic calcium phosphate crystals within the collagen fibrils (as shown using TEM, EDX and SAED). This work demonstrates how simple inorganic ions can have potent effects on structuring biological precipitates and suggests why trace quantities of silicon ions are essential to the formation of healthy hard tissues.
机译：图案化矿化是许多硬组织的特征。由这种组织表现出的令人印象深刻的机械性能可以部分地归因于有机基质内矿物质的图案化沉积。虽然没有热力学上有利，但胶原纤维内的磷酸钙矿物质的沉积发生在骨和牙本质中的体内。因此，许多研究人员研究了如何将基质蛋白质调节以使得能够进行图案化矿物沉积以重新承载本质上发现的结构。在这项研究中，我们已经证明了胶原蛋白类型的这种图案化的矿化可以简单地通过用硅酸（OSA）预处理胶原蛋白的预处理。胶原蛋白的OSA处理导致胶原纤维的结构变化，改变原纤维直径并改变纤维形成的动力学。 NMR证明，OSA优先位于原胶原原纤维的末端，从而模板在胶原型原纤维内的形成磷酸钙晶体（如使用TEM，EDX和SAED所示）。这项工作证明了无机离子如何对结构性生物沉淀物具有有效的影响，并且表明痕量的硅离子对形成健康硬组织至关重要。

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