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首页> 外文期刊>RSC Advances >Facile synthesis of novel hydrophilic and carboxyl-amine functionalized superparamagnetic iron oxide nanoparticles for biomedical applications
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Facile synthesis of novel hydrophilic and carboxyl-amine functionalized superparamagnetic iron oxide nanoparticles for biomedical applications

机译：基于新型亲水性和羧基胺官能化超顺磁性氧化物纳米粒子的体育合成

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In this work, we aim to synthesize water soluble and surface functionalized superparamagnetic iron oxide nanoparticles (SPIONs) using novel surfactants such as terephthalic acid (TA), 2-aminoterephthalic acid (ATA), trimesic acid (TMA) and pyromellitic acid (PMA) through one-step facile chemical co-precipitation and thermal decomposition methods. The as-synthesized SPIONs are characterized using X-ray diffraction (XRD), transmission electron microscopy (TEM), dynamic light scattering (DLS) measurements, Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA) and vibrating sample magnetometer (VSM). The as-synthesized SPIONs showed very good water solubility and a high magnetization value ( M _(s) = 55–73 emu g ~(?1) ). Furthermore, the as-synthesized ATA-coated SPIONs are conjugated with a fluorophore (Alexa Fluor 488) to demonstrate their ability for further chemical/biological conjugation without any additional surface modifications. Moreover, above 90% cell viability in MCF-7 cancer cells has been observed, thus confirming good cytocompatibility of the SPIONs. Therefore, these hydrophilic and carboxyl-amine functionalized SPIONs are very promising candidates to be used for biomedical applications.
机译：在这项工作中，我们的目标是使用新型表面活性剂如对苯二甲酸（Ta），2- amotophalic acid（ATA），微金属酸（TMA）和吡啉酸（PMA），合成水溶性和表面官能化的超顺磁性氧化物纳米颗粒（胶片）通过一步化学化学共析和热分解方法。用X射线衍射（XRD），透射电子显微镜（TEM），动态光散射（DLS）测量，傅里叶变换红外光谱（FTIR），热重分析（TGA）和振动样品磁力计（VSM ）。作为合成的散热性显示出非常好的水溶性和高磁化值（M _（S）= 55-73 emu g〜（α1））。此外，用荧光团（Alexa Fluor 488）缀合的AS合成的ATA涂覆的散配，以证明其进一步的化学/生物缀合能力而无需任何额外的表面修饰。此外，已经观察到在MCF-7癌细胞中90％的细胞活力，从而证实了浇口的良好细胞偶联性。因此，这些亲水性和羧基 - 胺官能化栓状物是用于生物医学应用的非常有希望的候选物。

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