• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>RSC Advances >Two chiral alkanolamine Schiff base Cu(ii) complexes as potential anticancer agents: synthesis, structure, DNA/protein interactions, and cytotoxic activity
【24h】

Two chiral alkanolamine Schiff base Cu(ii) complexes as potential anticancer agents: synthesis, structure, DNA/protein interactions, and cytotoxic activity

机译：两种手性链烷醇胺席夫基铜（II）复合物作为潜在的抗癌剂：合成，结构，DNA /蛋白质相互作用和细胞毒性活性

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Two Schiff base copper( II ) complexes, [Cu( R -L) (CH _(3) OH)] _(8) ( 1 ) and [Cu( S -L) (CH _(3) OH)] _(4) ( 2 ) {[ R / S -H _(2) L = R / S -3-phenyl-2-(2-hydroxy-5-chlorobenzylideneamino)propane-1-ol]}, have been successfully achieved and fully characterized by single-crystal X-ray diffraction (SXRD), mass spectrometry (MS), Fourier transform infrared spectroscopy (FT-IR), and elemental analysis (EA). The interactions of complexes 1 and 2 with calf thymus DNA (CT-DNA) and bovine serum albumin (BSA) have been comprehensively investigated using various electronic absorption spectroscopies. The thermal denaturation, viscosity, and UV-Vis spectra data suggested non-intercalative binding between DNA and the complexes. Additionally, an in vitro cytotoxicity test on the two complexes towards four types of human cancerous cell lines (HL-60, Caco-2, A549, and HeLa) indicated that the two complexes exhibited substantial cytotoxic activity. Especially, complex 2 exhibited excellent data, with IC _(50) = 10.97 ± 1.22 against HL-60 cells, which indicated that the two chiral complexes play significant roles in the cytotoxicity and interactions with DNA and BSA.
机译：两个席夫基铜（II）配合物，[Cu（R-1）（CH _（3）OH）] _（8）（1）和[Cu（S -L）（CH _（3）OH）] _ （4）（2）（[r / s-h _（2）l = r / s -3-苯基-2-（2-羟基-5-氯苄基氨基）丙烷-1-ol]}已成功实现并充分以单晶X射线衍射（SXRD），质谱（MS），傅里叶变换红外光谱（FT-IR）和元素分析（EA）的特征。通过各种电子吸收光谱全面研究了复合物1和2与小牛胸腺DNA（CT-DNA）和牛血清白蛋白（BSA）的相互作用。热变性，粘度和UV-Vis谱数据建议DNA和复合物之间的非间隔性结合。另外，两种络合物上的体外细胞毒性试验朝向四种类型的人类癌细胞系（HL-60，Caco-2，A549和HeLa）表明，两种络合物表现出大量细胞毒性活性。特别是，复合物2表现出优异的数据，IC _（50）= 10.97±1.22针对HL-60细胞，这表明两种手性复合物在细胞毒性和与DNA和BSA的相互作用中起显着作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号