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首页> 外文期刊>RSC Advances >A novel nano-silver coated and hydrogel-impregnated polyurethane nanofibrous mesh for ventral hernia repair
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A novel nano-silver coated and hydrogel-impregnated polyurethane nanofibrous mesh for ventral hernia repair

机译：一种新型纳米银涂层和水凝胶浸渍的聚氨酯纳米纤维纳米纤维网，用于腹侧疝修复

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Clinically, patches for hernia repair have two existing concerns: antibacterial and tissue adhesion. The modification of medical device surfaces with antibacterial properties has recently shown to be an effective means to control bacterial-caused infection. On the other hand, hydrogel of gelatin and polyethylene glycol (PEG) has been verified for reducing tissue adhesion. Herein, we report a novel muscle-inspired and nano-silver coated, polyethyleneglycol (PEG)/gelatin hydrogel-impregnated polyurethane (NSPU) mesh. We hypothesize that an outside coated nano-silver is antiseptic to inflammations and infection. The PEG and gelatin hydrogel can remarkably reduce the postoperative adhesion in the abdomen; moreover, the flexible nanofibrous PU provides the necessary mechanical support as well. The composite mesh exhibited good antibacterial property in vitro . In vivo , after the implantation, it significantly reduced the postoperative adhesion in the abdomen compared to commercial polypropylene (PP) meshes. The composite also shows the graft accommodation in the abdominal wall tissue from hematoxylin–eosin (HandE) staining and immunohistochemistry analysis of CD3 (lymphocyte), CCR7 (M1 phenotype macrophage) and CD163 (M2 phenotype macrophage). Therefore, our NSPU mesh is promising for ventral hernia repair.
机译：临床上，疝修补的补丁具有两个现有问题：抗菌和组织粘附。最近，具有抗菌性能的医疗器械表面的改性是控制细菌引起的感染的有效手段。另一方面，已经验证了明胶和聚乙二醇（PEG）的水凝胶以降低组织粘附。在此，我们报告了一种新型肌肉启发和纳米银涂覆的聚乙二醇（PEG）/明胶水凝胶浸渍的聚氨酯（NSPU）网。我们假设外部涂覆的纳米银是灭菌和感染的防腐剂。 PEG和明胶水凝胶可以显着降低腹部的术后粘附;此外，柔性纳米纤维PU也提供了必要的机械载体。复合网格在体外表现出良好的抗菌性质。在体内，在植入之后，与商业聚丙烯（PP）网格相比，它显着降低了腹部的术后粘附。该复合材料还示出了来自苏木精 - 曙红（手工）染色和CD3（淋巴细胞），CCR7（M1表型巨噬细胞）和CD163（M2表型巨噬细胞）的免疫组织化学分析的腹壁组织中的移植物容纳。因此，我们的NSPU网格对腹疝修复有前途。

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