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Synthesis of azo carbonate monomers and biocompatibility study of poly(azo-carbonate-urethane)s

机译：偶氮碳酸偶氮酯单体的合成及多（碳酸亚碳酸亚氨基甲酸酯）的生物相容性研究

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The present work describes the synthesis of azo carbonate monomers by a clean carbonylation synthetic route using di-methylcarbonate. The kinetics study showed a conversion of ～98% to bis-carbonates after only six minutes of reaction using triazabicyclo[4.4.0]dec-5-ene (TBD) as the catalyst. The preparation of azo-carbonates by means of coupling aryldiazonium salts with bis-carbonate was performed. The reactivity of azo-carbonate monomers was tested in the polycondensation reaction with an aminoalcohol using TBD as a catalyst for the formation of non-isocyanate poly(azo-carbonate-urethane)s PCU 1 and PCU 2 . The copolymers’ structures were confirmed by FT-IR, NMR and MALDI experiments, which allow us to determine the different terminal groups of the polymer chains formed. The molecular weights and the molecular weight distribution of PCU 1 and PCU 2 were determined by size-exclusion chromatography (SEC) experiments and thermal stabilities were also studied by TG analysis. The biocompatible properties of monomers 4 and 6 and polymers PCU 1 and PCU 2 were investigated by liver, kidney and colon histological analyses.
机译：本作者通过使用二甲基丙酯通过清洁羰基化合成途径来描述偶氮碳酸酯单体的合成。动力学研究表明，在使用三氮杂双环[4.4.0] DEC-5-ENE（TBD）作为催化剂的反应仅6分钟后，对双碳酸酯表示〜98％的转化率。通过用双碳酸酯偶联偶氮盐的偶氮碳酸盐制备。使用TBD作为非异氰酸酯聚（偶氮酯 - 氨基甲酸酯）的PCU 1和PCU 2的催化剂，在缩聚反应中与氨基醇的常羟醇中的缩聚反应中测试偶氮硅酸酯单体的反应性。通过FT-IR，NMR和MALDI实验证实共聚物结构，使我们能够确定形成的聚合物链的不同末端基团。分子量和PCU 1和PCU 2的分子量分布通过尺寸排阻色谱（SEC）实验和TG分析研究了热稳定性。通过肝脏，肾和结肠组织学分析研究单体4和6和聚合物PCU 1和PCU 2的生物相容性。

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