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A highly sensitive fluorescent probe for detection of hydrazine in gas and solution phases based on the Gabriel mechanism and its bioimaging

机译：基于Gabriel机制及其生物分析，一种高敏感的荧光探针，用于检测气体和溶液阶段的肼和溶液相

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摘要

A new probe 2-benzo[1,2,5]thiadiazol-4-yl-isoindole-1,3-dione ( BTI ) based on the Gabriel reaction mechanism was synthesized and characterized for the specific detection of hydrazine with high selectivity against other amines in an organo-aqueous solution. Upon hydrazinolysis of BTI in the presence of hydrazine in a H _(2) O–DMSO (4?:?6, v/v) solution (10 mM HEPES buffer, pH 7.4) at room temperature, the chemosensor produces fluorescent aminobenzthiadiazole with a maximum emission at 498 nm along with a color change from colorless to green, allowing selective colorimetric and fluorometric detection of hydrazine by the naked eye. Probe BTI was also successfully applied in vapor phase hydrazine detection into a solid state over other interfering volatile analytes. Furthermore, the probe BTI coated with silica gel TLC plates could act as a visual and fluorimetric probe for hydrazine vapor detection. The experimental detection limit of hydrazine is 2.9 ppb, which is well below the accepted limit (10 ppb) for hydrazine set by the U.S. Environmental Protection Agency (EPA). DFT and TDDFT calculations were performed in order to demonstrate the sensing mechanism and the electronic properties of probe and hydrazinolysis products. Additionally, probe BTI could also be applied for the imaging of hydrazine in living cells.
机译：合成了新的探针2-苯并[1,2,5]噻二唑-4-基甲基吲哚-1,3-二酮（BTI），合成，其特征在于对其他具有高选择性的肼的特异性检测有机溶液中的胺。在室温下在H _（2）O-DMSO（4？：β6，V / V）溶液（10mM HEPES缓冲液，pH7.4）中的肼存在下BTI的肼分解时，化学传感器产生荧光氨基苯二唑498nm的最大发射以及从无色到绿色的颜色变化，允许通过肉眼选择性比色和缺水率。探针BTI还成功地将气相肼检测施用成固体状态，在其它干扰挥发性分析物中。此外，涂有硅胶TLC板的探针BTI可以用作用于肼蒸汽检测的视觉和荧光探针。肼的实验检测限为2.9ppb，远低于美国环境保护局（EPA）的肼的可接受的极限（10 ppb）。进行DFT和TDDFT计算，以证明探针和肼分解产物的传感机制和电子性质。另外，探针BTI也可以应用于活细胞中的肼成像。

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