Identification of novel thermostable ω-transaminase and its application for enzymatic synthesis of chiral amines at high temperature

Sam Mathew; Kanagavel Deepankumar; Giyoung Shin; Eun Young Hong; Byung-Gee Kim; Taeowan Chung; Hyungdon Yun

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Identification of novel thermostable ω-transaminase and its application for enzymatic synthesis of chiral amines at high temperature

机译：新型热稳定ω-转氨酶鉴定及其在高温下酶合成酶合成的应用

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A novel thermostable ω-transaminase from Thermomicrobium roseum which showed broad substrate specificity and high enantioselectivity was identified, expressed and biochemically characterized. The advantage of this enzyme to remove volatile inhibitory by-products was demonstrated by performing asymmetric synthesis and kinetic resolution at high temperature.

机译：鉴定了来自Heartumcrobium roseum的新型热稳定ω-转氨酶，其显示出宽的底物特异性和高对映射性，表达和生物化学表征。通过在高温下进行不对称合成和动力学分辨率，证明了这种酶除去挥发性抑制副产物的优点。

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《RSC Advances》 |2016年第73期|共4页
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Sam Mathew; Kanagavel Deepankumar; Giyoung Shin; Eun Young Hong; Byung-Gee Kim; Taeowan Chung; Hyungdon Yun;
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1. Identification of novel thermostable omega-transaminase and its application for enzymatic synthesis of chiral amines at high temperature [J] . Mathew Sam, Deepankumar Kanagavel, Shin Giyoung, RSC Advances . 2016,第73期

机译：新型热稳定ω-转氨酶鉴定及其在高温下酶合成酶合成的应用
2. Identification of novel thermostable taurine-pyruvate transaminase from Geobacillus thermodenitrificans for chiral amine synthesis [J] . Chen Yujie, Yi Dong, Jiang Shuiqin, Applied Microbiology and Biotechnology . 2016,第7期

机译：鉴定新型热稳定性牛磺酸酪氨酸-丙酮酸转氨酶用于手性胺的合成
3. An efficient single-enzymatic cascade for asymmetric synthesis of chiral amines catalyzed by ω-transaminase [J] . Bo Wang, Henrik Land, Per Berglund Chemical Communications . 2013,第2期

机译：有效的单酶级联反应，用于ω-转氨酶催化的不对称合成手性胺
4. DEVELOPMENT AND APPLICATION OF NOVEL ENGINEERED TRANSAMINASE PANELS ASSISTED BY IN-SILICO RATIONAL DESIGN FOR THE PRODUCTION OF CHIRAL AMINES [C] . Daniel F.A.R. Dourado, Stefan Pohle, Jill Caswell, Conference on biochemical and molecular engineering . 2019

机译：硅胶合理设计用于手性胺生产的新型工程化转氨酶面板的开发与应用
5. Preparation and Applications of Perfluorobutanesulfinamide for the Asymmetric Synthesis of Chiral Branched Amines. [D] . Wangweerawong, Apiwat. 2016

机译：全氟丁烷亚磺酰胺的不对称合成手性支链胺的制备及应用。
6. Chiral Amine Synthesis Using ω-Transaminases: An Amine Donor that Displaces Equilibria and Enables High-Throughput Screening [O] . Anthony P Green, Nicholas J Turner, Elaine OReilly -1

机译：使用ω-转氨酶的手性胺合成：取代平衡并实现高通量筛选的胺供体
7. Inside Cover: Immobilization of two (R)-Amine Transaminases on an Optimized Chitosan Support for the Enzymatic Synthesis of Optically Pure Amines (ChemCatChem 2/2013) [O] . Hendrik Mallin, Ulf Menyes, Torge Vorhaben, 2013

机译：内盖：固定两种（R）-amine转氨酶对优化的壳聚糖载体，用于酶促合成光学纯胺（Chemcatchem 2/2013）

Identification of novel thermostable ω-transaminase and its application for enzymatic synthesis of chiral amines at high temperature

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