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首页> 外文期刊>RSC Advances >Delayed hepatic uptake of multi-phosphonic acid poly(ethylene glycol) coated iron oxide measured by real-time magnetic resonance imaging
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Delayed hepatic uptake of multi-phosphonic acid poly(ethylene glycol) coated iron oxide measured by real-time magnetic resonance imaging

机译：通过实时磁共振成像测量的多膦酸聚（乙二醇）涂层氧化铁的延迟肝脏吸收

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摘要

We report on the synthesis, characterization, stability and pharmacokinetics of novel iron based contrast agents for magnetic resonance imaging (MRI). Statistical copolymers combining multiple phosphonic acid groups and poly(ethylene glycol) (PEG) were synthesized and used as coating agents for 10 nm iron oxide nanocrystals. In vitro , protein corona and stability assays show that phosphonic acid PEG copolymers outperform all other coating types examined, including low molecular weight anionic ligands and polymers. In vivo , the particle pharmacokinetics is investigated by monitoring the MRI signal intensity from mouse liver, spleen and arteries as a function of time, between one minute and seven days after injection. Iron oxide particles coated with multi-phosphonic acid PEG polymers are shown to have a blood circulation lifetime of 250 minutes, i.e. 10 to 50 times greater than that of recently published PEGylated probes and benchmarks. The clearance from the liver takes in average 2 to 3 days and is independent of the core size, coating and particle stability. By comparing identical core particles with different coatings, we are able to determine the optimum conditions for stealth MRI probes.
机译：我们报告了用于磁共振成像（MRI）的新型铁基造影剂的合成，表征，稳定性和药代动力学。合成了多种膦酸基团和聚（乙二醇）（PEG）的统计共聚物被合成并用作涂布剂10nm氧化铁纳米晶体。体外，蛋白质电晕和稳定性测定表明，膦酸PEG共聚物优于检查的所有其他涂层类型，包括低分子量阴离子配体和聚合物。在体内，通过将来自小鼠肝脏，脾脏和动脉的MRI信号强度作为时间的函数，在注射后1分钟至七天之间监测MRI信号强度来研究颗粒药代动力学。涂有多膦酸PEG聚合物的氧化铁颗粒被显示为血液循环寿命为250分钟，即大于最近公开的PEG化探针和基准的10至50倍。肝脏的间隙平均为2至3天，与芯尺寸，涂层和颗粒稳定性无关。通过将相同的核心颗粒与不同的涂层进行比较，我们能够确定隐形MRI探针的最佳条件。

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